Results 241 to 250 of about 15,813,897 (314)

Clinical indicators for dose re-optimization in magnetic resonance-guided online adaptive radiotherapy for prostate cancer. [PDF]

Phys Imaging Radiat Oncol
Nishitani M, Okamoto H, Chang W, Kuwahara J, Chiba T, Sakasai T, Nakayama H, Inaba K, Kashihara T, Nakamura S, Nakaichi T, Goka T, Igaki H.   +12 more
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Predicting patient-specific quality assurance outcomes in helical tomotherapy using plan complexity and 3D dose-distribution radiomics. [PDF]

Front Oncol
Jin X, Xiao X, Guo R, Chen T, Hu C.
europepmc   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Clinical Comparison of Beam-Specific Planning Target Volume Single-Field Uniform Dose and Robust Intensity-Modulated Proton Therapy in Ultra-Hypofractionation for Prostate Cancer. [PDF]

Int J Part Ther
Tamura H, Yoshimura T, Nakazato K, Yoshimoto H, Takao S, Matsuura T, Mori T, Nishioka K, Kobashi K, Hashimoto T, Aoyama H.   +10 more
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Framing sustainability in Milan's urban policies: new coalitions in a molecular transition. [PDF]

Front Sociol
Bernardi M, Manzano C, Cancellieri A, Tosi S.   +3 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Early Intervention and Remediation in Family Medicine Residencies: Behavioral Science Faculty Ratings of the Integration of Consensus-Based Recommendations. [PDF]

Fam Med
Haymaker CM, Schilling J, Fraser K, Romain A, Delbridge E, Cadick A, Arthur ME, Pratt G, Malhotra K, Brubaker A.   +9 more
europepmc   +1 more source