Results 271 to 280 of about 20,516,146 (337)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

GEODESY IN SOLVING PROBLEMS OF SUSTAINABLE CITY DEVELOPMENT: ANALYSIS OF URBAN TERRITORY PLANNING

Vasyl Goi, Mykola Kharkhalis, V. S. Fomenko   +2 more
openalex   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Decolonizing infectious disease programs: A mixed methods analysis of a novel multi-country virtual training for Female Genital Schistosomiasis. [PDF]

PLOS Glob Public Health
Eller K, Nwoku KA, Sadki R, Vecchio N, Pensotti C, Mbuh CN, Jacobson J.   +6 more
europepmc   +1 more source

Integrative Synergies between BRI of China and Agenda 2063 of African Union: Reviewing the Policy Documents and Analyzing the Program for Infrastructure Development in Africa-Priority Action Plan 2 (PIDA-PAP 2) (2021-2030)

Muhammad Amjad Raza, Abdul Basit Khan
openalex   +2 more sources

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Task sharing for point-of-care testing: Review of national health policies and implementation landscape in 19 African countries. [PDF]

PLOS Glob Public Health
Ndlovu Z, Assane MI, Ocen F, Lamou KC, Mandona M, Mphande-Nyasulu F, Kabwe E, Fongwen NT, Said HM, Emmanuel O, Elom E, Chipuka S, Nabadda S, Bitilinyu-Bangoh J, Lesuk G, Bowen N, Adama D, Mlisana K, George JA, Melese D, Ayana G, Ndombe R, Johnson CC, Bekelynck A, Ondoa P, Loembé MM, Ellman T, Ndlovu N, Fatti G, Otieno Odhiambo C.   +29 more
europepmc   +1 more source

Promoting Family Planning in Matameye: A Path to Family Well-Being and Sustainable Development

A.Z Mahamadou Nourou, Olalekan Moses Olayemi, Bahiyah Omar   +2 more
openalex   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Joint Adaptation of a Digital Mental Health Intervention for University Students: Inductive Qualitative Analysis. [PDF]

J Particip Med
Dooley J, Alsaadi N, Watkins E.
europepmc   +1 more source