Results 91 to 100 of about 2,013,928 (265)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Immunogenicity and Safety of a Quadrivalent Meningococcal Conjugate Vaccine (MenACYW-TT) Administered with Routine Pediatric Vaccines: A European Randomized Controlled Trial

Infectious Diseases and Therapy
Introduction The immunogenicity and safety of MenACYW-TT (MenQuadfi®) were compared to another quadrivalent meningococcal conjugate vaccine, MCV4-TT (Nimenrix®), when administered in infants alongside routine childhood vaccines in Europe. Methods One set
Federico Martinon-Torres, Miia M. Virta, Susanna Koski, Ignacio Salamanca de la Cueva, Henryk T. Szymanski, Samantha Bosis, Anca C. Drăgănescu, Sven-Arne Silfverdal, Betzana Zambrano, Mandeep S. Dhingra, Siham B’Chir, Olga Syrkina, Olga Lyabis, Gustavo A. Vasquez, Christine Rehm, The MET58 Study Group   +15 more
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Toward a Long-Term Low Emission Development Strategy: The Case of Energy Transition in Qatar. [PDF]

Glob Chall, 2023
Al-Noaimi F, Al-Ansari T, Bicer Y.
europepmc   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Homeostasis imbalance process ontology: a study on COVID-19 infectious processes

BMC Medical Informatics and Decision Making
Background One significant challenge in addressing the coronavirus disease 2019 (COVID-19) pandemic is to grasp a comprehensive picture of its infectious mechanisms.
Yuki Yamagata, Tatsuya Kushida, Shuichi Onami, Hiroshi Masuya   +3 more
doaj   +1 more source

Competencies Development Strategy Using Augmented Reality for Self-Management of Learning in Manufacturing Laboratories (AR-ManufacturingLab). [PDF]

Heliyon, 2023
Hernández-Rodríguez F, Guillén-Yparrea N.   +1 more
europepmc   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Research on an Ecological Sensitivity Evaluation of Mountain-Type National Parks Under Multi-Modal Optimization: A Case Study of Shennongjia, China

Land
As ecologically sensitive zones within natural ecosystems, national parks demand more precise evaluation models for ecological sensitivity assessment. This study takes Shennongjia Forestry District, a pioneer among China’s first-batch national parks, as ...
Xingyu Zhou, Huan Huang, Shi Dai, Duanya Zheng, Jie Zhao   +4 more
doaj   +1 more source

Corporate Sustainability Development Strategy and Corporate Environmental Governance-The Moderating Role of Corporate Environmental Investments. [PDF]

Int J Environ Res Public Health, 2023
Ao X, Ong TS, Teh BH.
europepmc   +1 more source