Results 101 to 110 of about 2,055,307 (265)

Research on an Ecological Sensitivity Evaluation of Mountain-Type National Parks Under Multi-Modal Optimization: A Case Study of Shennongjia, China

Land
As ecologically sensitive zones within natural ecosystems, national parks demand more precise evaluation models for ecological sensitivity assessment. This study takes Shennongjia Forestry District, a pioneer among China’s first-batch national parks, as ...
Xingyu Zhou, Huan Huang, Shi Dai, Duanya Zheng, Jie Zhao   +4 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

CpG dinucleotide enrichment in the influenza A virus genome as a live attenuated vaccine development strategy. [PDF]

PLoS Pathog, 2023
Sharp CP, Thompson BH, Nash TJ, Diebold O, Pinto RM, Thorley L, Lin YT, Sives S, Wise H, Clohisey Hendry S, Grey F, Vervelde L, Simmonds P, Digard P, Gaunt ER.   +14 more
europepmc   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Multi-Targets: An Unconventional Drug Development Strategy for Alzheimer's Disease. [PDF]

Front Aging Neurosci, 2022
Gong CX, Dai CL, Liu F, Iqbal K.
europepmc   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Retracted: Development Strategy of College Sports Information Management System Using Data Mining in Mobile Internet Environment. [PDF]

J Environ Public Health, 2023
Environmental And Public Health JO.
europepmc   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Assessment of transmission network connection solutions based on HVAC for offshore wind

IET Generation, Transmission & Distribution
The diffusion of offshore wind power plants (OWPPs), useful to fulfil renewable diffusion policy targets, implies several technological challenges for integration in power transmission network.
Mattia Deriu, Michela Migliori, Corrado Gadaleta, Marco Cortese, Enrico Maria Carlini, Maria Dicorato, Giuseppe Forte, Gioacchino Tricarico   +7 more
doaj   +1 more source

Like the new and hate the old: The impact of fiscal decentralization on regional development strategy. [PDF]

PLoS One, 2022
Liu M, Gong F, Song W.
europepmc   +1 more source