The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
CpG dinucleotide enrichment in the influenza A virus genome as a live attenuated vaccine development strategy. [PDF]
PLoS Pathog, 2023 Sharp CP +14 more
europepmc +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Multi-Targets: An Unconventional Drug Development Strategy for Alzheimer's Disease. [PDF]
Front Aging Neurosci, 2022 Gong CX, Dai CL, Liu F, Iqbal K.
europepmc +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Assessment of transmission network connection solutions based on HVAC for offshore wind
IET Generation, Transmission & DistributionThe diffusion of offshore wind power plants (OWPPs), useful to fulfil renewable diffusion policy targets, implies several technological challenges for integration in power transmission network.
Mattia Deriu +7 more
doaj +1 more source
Retracted: Development Strategy of College Sports Information Management System Using Data Mining in Mobile Internet Environment. [PDF]
J Environ Public Health, 2023 Environmental And Public Health JO.
europepmc +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Like the new and hate the old: The impact of fiscal decentralization on regional development strategy. [PDF]
PLoS One, 2022 Liu M, Gong F, Song W.
europepmc +1 more source