Results 201 to 210 of about 2,597,153 (267)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

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Sepsis Strategies in Development

Clinics in Chest Medicine, 2008
Severe sepsis, defined as inflammation and organ failure due to infection, continues to result in a mortality of approximately 30% despite advances in critical care. Current therapy includes timely administration of antibiotics, source control of infection, aggressive fluid resuscitation, support of failing organs, and use of activated protein C where ...
Steven P, LaRosa, Steven M, Opal
openaire   +2 more sources

Strategies for the development of metalloimmunotherapies

Nature Biomedical Engineering
Metal ions play crucial roles in the regulation of immune pathways. In fact, metallodrugs have a long record of accomplishment as effective treatments for a wide range of diseases. Here we argue that the modulation of interactions of metal ions with molecules and cells involved in the immune system forms the basis of a new class of immunotherapies.
Xiaoqi Sun, Xingwu Zhou, Xiaoyue Shi, Omar A. Abed, Xinran An, Yu Leo Lei, James J. Moon   +6 more
openaire   +2 more sources

Strategies for the Development of a Territory

2014 14th International Conference on Computational Science and Its Applications, 2014
Territorial marketing extends marketing from the company to the territorial contexts and much value at this regard is assumed by the Van den Berg's consideration [1], according to whom "a city should be managed as a business enterprise", where the orientation to the market constitutes an indispensable reference.
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Strategy For Development Administration

Journal of the Community Development Society, 1975
Neither development nor administration is static. In the past twenty years there have been major changes in both development and administration — changes in theory and in practice. Therefore, a consideration of strategy for development administration must begin with an examination of the evolution and prospects of the theory and practice of both ...
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Developing an is Education Strategy

Information Systems Management, 2001
Abstract Business firms are increasingly concerned with the education and learning of their employees.They recognize that their human capital is their most valuable resource, and they want to enhance their organization's effectiveness by ensuring that their people continue to develop intellectually.
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Development of rewriting strategies

1993
Algebraic program is considered as a system of rewriting rules jointly with rewriting strategy that may be represented in procedural form. The optimization of an algebraic program therefore is reduced to the development of optimal strategy and optimal implementation of it. This paper is devoted to the problem of finding optimal strategies for the given
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A Strategy for Development [PDF]

, 2002
This book is about a collection of speeches -all delivered since Nicholas Stern became Chief Economist of the World Bank in July 2000- they reflect insights that Mr. Stern has gained over more than three decades of study and work in development economics.
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