Results 181 to 190 of about 1,157,389 (344)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Advancing developmental biology in Central Europe: report from the V4SDB meeting 2025. [PDF]

Biol Open
Kompaníková P, Attri K, Czimer D, Hubiernatorova A, Trela-Kobędza E, Zimčík D.   +5 more
europepmc   +1 more source

Editorial: Emerging frontiers in developmental biology in Latin America. [PDF]

Front Neurosci, 2023
Ortuño-Sahagún D, Riesgo-Escovar JR.
europepmc   +1 more source

Developmental biology in Australia and New Zealand [PDF]

, 2002
Brian Key, Ian McLennan
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

How to lose a whorl: the evolutionary and developmental biology of apetaly. [PDF]

J Exp Bot
Cronk QCB.
europepmc   +1 more source

Unravelling the sexual developmental biology of Cystoisospora suis, a model for comparative coccidian parasite studies. [PDF]

Front Cell Infect Microbiol, 2023
Cruz-Bustos T, Dolezal M, Feix AS, Ruttkowski B, Hummel K, Razzazi-Fazeli E, Joachim A.   +6 more
europepmc   +1 more source

USSR Space Life Sciences Digest, issue 13 [PDF]

This is the thirteenth issue of NASA's USSR Space Life Sciences Digest. It contains abstracts of 39 papers recently published in Russian-language periodicals and bound collections, two papers delivered at an international life sciences symposium, and ...
Hooke, Lydia Razran, Teeter, Ronald, Teeter, Ronald, Teeter, Ronald, Teeter, Ronald   +4 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

When imaging technology meets single-cell omics: new paradigm in developmental biology. [PDF]

Cell Regen
Wang C, Zhang X, Zhang Y, Liu F.
europepmc   +1 more source