The clinical spectrum of SMA‐PME and in vitro normalization of its cellular ceramide profile
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1941-1952, December 2022., 2022 Abstract Objective The objectives of this study were to define the clinical and biochemical spectrum of spinal muscular atrophy with progressive myoclonic epilepsy (SMA‐PME) and to determine if aberrant cellular ceramide accumulation could be normalized by enzyme replacement.
Michelle M. Lee +16 more
wiley +1 more source
Phosphorylation of Spastin Promotes the Surface Delivery and Synaptic Function of AMPA Receptors
Frontiers in Cellular Neuroscience, 2022 Synaptic plasticity is essential for cognitive functions such as learning and memory. One of the mechanisms involved in synaptic plasticity is the dynamic delivery of AMPA receptors (AMPARs) in and out of synapses.
Li Chen +8 more
doaj +1 more source
Recognizing early MRI signs (or their absence) is crucial in diagnosing metachromatic leukodystrophy
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1999-2009, December 2022., 2022 Abstract Objectives Metachromatic leukodystrophy (MLD) has characteristic white matter (WM) changes on brain MRI, which often trigger biochemical and genetic confirmation of the diagnosis. In early or pre‐symptomatic disease stages, these typical MRI changes might be absent, hampering early diagnosis.
Daphne H. Schoenmakers +7 more
wiley +1 more source
Gaining insight into adolescent vulnerability for social anxiety from developmental cognitive neuroscience. [PDF]
Dev Cogn Neurosci, 2014 Caouette JD, Guyer AE.
europepmc +2 more sources
Comprehensive Analysis of lncRNAs, miRNAs and mRNAs in Mouse Hippocampus With Hepatic Encephalopathy
Frontiers in Genetics, 2022 Hepatic encephalopathy (HE) often presents with varying degrees of cognitive impairment. However, the molecular mechanism of its cognitive impairment has not been fully elucidated.
Huijie Zhang +14 more
doaj +1 more source
Are advanced methods necessary to improve infant fNIRS data analysis? An assessment of baseline-corrected averaging, general linear model (GLM) and multivariate pattern analysis (MVPA) based approaches [PDF]
Neuroimage, 2022, 119756, 2022 In the last decade, fNIRS has provided a non-invasive method to investigate neural activation in developmental populations. Despite its increasing use in developmental cognitive neuroscience, there is little consistency or consensus on how to pre-process and analyse infant fNIRS data.
arxiv +1 more source
Social re-orientation and brain development: An expanded and updated view. [PDF]
, 2016 Social development has been the focus of a great deal of neuroscience based research over the past decade. In this review, we focus on providing a framework for understanding how changes in facets of social development may correspond with changes in ...
Guyer, Amanda E +2 more
core +8 more sources
Strategies for Targeting Neural Circuits: How to Manipulate Neurons Using Virus Vehicles
Frontiers in Neural Circuits, 2022 Viral strategies are the leading methods for mapping neural circuits. Viral vehicles combined with genetic tools provide the possibility to visualize entire functional neural networks and monitor and manipulate neural circuit functions by high-resolution
Yuqing Hui +10 more
doaj +1 more source
A Whole Brain Probabilistic Generative Model: Toward Realizing Cognitive Architectures for Developmental Robots [PDF]
Neural Networks, 2022, Volume 150, 293-312, 2021 Building a humanlike integrative artificial cognitive system, that is, an artificial general intelligence (AGI), is the holy grail of the artificial intelligence (AI) field. Furthermore, a computational model that enables an artificial system to achieve cognitive development will be an excellent reference for brain and cognitive science.
arxiv +1 more source
Developmental neuroscience of cognitive control: the futurepath and layout [PDF]
SCIENTIA SINICA Vitae, 2021 Cognitive control is the top-down process by which individuals store, plan, and manipulate relevant information through the deployment of resources during information processing. Cognitive control encompasses different research perspectives such as selective attention, conflict resolution, working memory, cognitive flexibility, and inhibitory control ...
Zhenghan Li +4 more
openaire +2 more sources