Results 111 to 120 of about 1,798,625 (305)
Pattern formation in spatially heterogeneous Turing reaction-diffusion models [PDF]
, 2003 The Turing reaction–diffusion model [Phil. Trans. R. Soc. 237 (1952) 37–72] for self-organised spatial pattern formation has been the subject of a great deal of study for the case of spatially homogeneous parameters.
Maini, P. K., Monk, N. A. M., Page, K.
core +2 more sources
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Parental Incarceration and Child Wellbeing: Implications for Urban Families [PDF]
Using a population-based, longitudinal family survey (N=4,898), we identify a set of economic, residential, and developmental risks particular to the children of incarcerated parents.
Amanda Geller +3 more
core
Vision and Reading Difficulties Part 1: Specific learning difficulties and vision [PDF]
, 2009 This article is the first in a series of five about vision and reading difficulties, and provides an introduction and an overview of learning disabilities and specific learning difficulties.
Allen, Peter M +2 more
core
, 2013 In this paper, we test the hypothesis that indices of nutritional stress from enamel hypoplasia increase the incidence of indicators of developmental instability in fluctuating asymmetry, even in high social status individuals.
A. Gawlikowska-Sroka +3 more
semanticscholar +1 more source
TREX1, a predator for treating MSI‐H tumors?
Molecular Oncology, EarlyView.Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya +2 more
wiley +1 more source
Journal of Pediatric Research, 2020 Aim:Developmental dysplasia of the hip is an orthopedic problem which is a spectrum of disorders from the instability of the hip joint to total dislocation.
Gizem Ürel Demir +6 more
doaj +1 more source
A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source