Stem-Like Adaptive Aneuploidy and Cancer Quasispecies [PDF]
, 2013 We analyze and reinterpret experimental evidence from the literature to argue for an ability of tumor cells to self-regulate their aneuploidy rate. We conjecture that this ability is mediated by a diversification factor that exploits molecular mechanisms
Napoletani, Domenico +2 more
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Journal of Methods and Measurement in the Social Sciences, 2021 Traditional theories of development and evolutionary developmental psychology propose that early environmental experiences shape an individual’s developmental trajectory.
Aurelio José Figueredo +2 more
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Developmental Origins of Limb Developmental Instability in Human Fetuses: Many Abnormalities Make the Difference [PDF]
Symmetry, 2017 Fluctuating asymmetry (FA) is the small random deviation from perfect symmetry in bilateral traits and is often used to assess developmental instability (DI) experienced by organisms. In this study, with a unique dataset of 1389 deceased human fetuses, we investigated the relationship between abnormal development and human limb FA in different ways ...
ten Broek, Claartje +4 more
openaire +4 more sources
Labyrinthine Turing Pattern Formation in the Cerebral Cortex [PDF]
, 2002 I propose that the labyrinthine patterns of the cortices of mammalian brains may be formed by a Turing instability of interacting axonal guidance species acting together with the mechanical strain imposed by the interconnecting axons.Comment: See home ...
BAIER +41 more
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Fluctuating asymmetry and developmental instability in Protoreaster nodosus (Chocolate Chip Sea Star) as a biomarker for environmental stress [PDF]
Computational Ecology and Software, 2015 Fluctuating asymmetry (FA), pertains to small and random departures from perfect symmetry of an organism's bilateral traits and has been used as a measurement of developmental instability and as a potential indicator of stress in populations. It measures
D. J. V. Trono +3 more
doaj
Hypoxia in the Initiation and Progression of Neuroblastoma Tumours [PDF]
, 2020 Neuroblastoma is the most frequent extracranial solid tumour in children, causing 10% of all paediatric oncology deaths. It arises in the embryonic neural crest due to an uncontrolled behaviour of sympathetic nervous system progenitors, giving rise to ...
Gómez Muñoz, María Ángeles +3 more
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Heterozygotic Brca1 mutation initiates mouse genome instability at embryonic stage
Oncogenesis, 2022 BRCA1 mutation is the genetic predisposition in causing genome instability towards cancer. BRCA1 mutation is predominantly germline inherited at the fertilization. However, when the inherited mutation initiates genome instability in the mutation carriers
Xiaobing Wu +4 more
doaj +1 more source
Prenatal Developmental Trajectories of Fluctuating Asymmetry in Bat Humeri
Frontiers in Cell and Developmental Biology, 2021 Fluctuating asymmetry (random fluctuations between the left and right sides of the body) has been interpreted as an index to quantify both the developmental instabilities and homeostatic capabilities of organisms, linking the phenotypic and genotypic ...
Camilo López-Aguirre +8 more
doaj +1 more source
Dissecting the dynamics of signaling events in the BMP, WNT, and NODAL cascade during self-organized fate patterning in human gastruloids. [PDF]
, 2019 During gastrulation, the pluripotent epiblast self-organizes into the 3 germ layers-endoderm, mesoderm and ectoderm, which eventually form the entire embryo.
Chhabra, Sapna +4 more
core +1 more source
Does the coefficient of variation reflect developmental instability in plants? [PDF]
Archives of Biological Sciences, 2005 Developmental stability or homeostasis refers to the ability of an individual to produce a consistent phenotype in a given environment (Graham et al. 1993). Reduced developmental stability can result from a wide variety of environmentally (or genetically)
Veličković Miroslava V. +1 more
doaj +1 more source