Results 81 to 90 of about 1,798,625 (305)

Evaluating the developmental instability of Scatophagus argus (Linnaeus, 1766) from Lower Agusan River Basin, Butuan City, Philippines using fluctuating asymmetry [PDF]

Computational Ecology and Software, 2016
Fluctuating Asymmetry (FA) is the most frequently used tool for measuring developmental instability. It is used as a measure of ecological stress and a sign of developmental stability of organisms.
J.H. Jumawan, J.P.B. Velasco, A.O. Mondejar, et al.   +2 more
doaj  

Elevated retrotransposon activity and genomic instability in primed pluripotent stem cells

Genome Biology, 2021
Background Naïve and primed pluripotent stem cells (PSCs) represent two different pluripotent states. Primed PSCs following in vitro culture exhibit lower developmental potency as evidenced by failure in germline chimera assays, unlike mouse naïve PSCs ...
Haifeng Fu, Weiyu Zhang, Niannian Li, Jiao Yang, Xiaoying Ye, Chenglei Tian, Xinyi Lu, Lin Liu   +7 more
doaj   +1 more source

Bet-hedging as a complex interaction among developmental instability, environmental heterogeneity, dispersal, and life-history strategy

Ecology and Evolution, 2014
One potential evolutionary response to environmental heterogeneity is the production of randomly variable offspring through developmental instability, a type of bet-hedging.
S. Scheiner
semanticscholar   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Family Structure and Secondary Exposure to Violence in the Context of Varying Neighborhood Risks and Resources

Socius, 2021
Secondary exposure to violence in the community is a prevalent developmental risk with implications for youths’ short- and long-term socioemotional functioning.
Haley Stritzel, Chelsea Smith Gonzalez, Shannon E. Cavanagh, Robert Crosnoe   +3 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Canalization and developmental stability of the yellow-necked mouse (Apodemus flavicollis) mandible and cranium related to age and nematode parasitism

Frontiers in Zoology, 2021
Background Mammalian mandible and cranium are well-established model systems for studying canalization and developmental stability (DS) as two elements of developmental homeostasis.
Vida Jojić, Borislav Čabrilo, Olivera Bjelić-Čabrilo, Vladimir M. Jovanović, Ivana Budinski, Mladen Vujošević, Jelena Blagojević   +6 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Pathways from caring and engaging adults to youth vocational identity: the mediational roles of career search self-efficacy and goal capacity [PDF]

, 2017
This study examines the role played by access to caring and engaging adults, career search self-efficacy (CSSE), and goal capacity in the development of youth vocational identity.
Chen, Zi, Solberg, V. Scott H.
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source