Results 91 to 100 of about 242,754 (286)

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Research on the effect of managerial pro-social rule breaking on miner safety deviance behavior

open access: yesMeikuang Anquan
In order to explore the influence mechanism of managerial pro-social rule breaking on miner safety deviance behavior, based on existing research, this study introduces the sense of self-control resource depletion threat, system awe, expected coworkers ...
Wenping LIU, Xiaoguang LIU
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Prisons in the Empire: specific features of the Russian penitentiary system in the 19th and early 20th centuries (a case study of Olonets province)

open access: yesStudia Humanitatis, 2019
The article describes the basic laws of the penitentiary system’s formation in the Olonets province. The author identifies main problems that existed in the operation of prisons in the province as well as the ways of interaction of various departments in
Pulkin Maxim Viktorovich
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Cum să abordăm diferenţele de vârstă şi gen în practica probaţiunii?

open access: yesSociologie Românească, 2010
This paper aims to explore the manner in which age and gender influence criminal behavior, criminal career and rehabilitation. We chose these two variables because in the literature they are often considered.
Ionela Vlase
doaj  

Student Perception of Parental Responses to Their Adolescent Behaviors: the Characteristics of Those Who are Labeled Negatively and the Impact of the Labels [PDF]

open access: yes, 2002
The following research uses labeling theory to determine what type of individual is most likely to be labeled negatively by their parents during adolescence. Labeling theory hypothesizes that if an individual is negatively labeled they are more likely to
Medley, Stephanie
core   +1 more source

Randomized Predictive P-values: A Versatile Model Diagnostic Tool with Unified Reference Distribution

open access: yes, 2019
Examining residuals such as Pearson and deviance residuals, is a standard tool for assessing normal regression. However, for discrete response, these residuals cluster on lines corresponding to distinct response values.
Feng, Cindy   +2 more
core   +1 more source

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