Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Mères sans mari. Filles-mères et abandons d’enfants (Paris, 1870-1920)
Genre & Histoire, 2016 From the beginning of the Third Republic to the close of the Great War, about 3,000 children were abandoned each year in Paris and taken in by the public care services (Assistance publique).
Antoine Rivière
doaj +1 more source
llc: a collection of R functions for fitting a class of Lee-Carter mortality models using iterative fitting algorithms [PDF]
, 2009 We implement a specialised iterative regression methodology in R for the analysis of age-period mortality data based on a class of generalised Lee-Carter (LC) type modelling structures.
Butt, Z., Haberman, S.
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Extending the Normativity of the Extended Family: Reflections on \u3ci\u3eMoore v. City of East Cleveland\u3c/i\u3e [PDF]
, 2017 Part I of this Article briefly recounts the plurality decision in Moore before analyzing Justice Brennan’s concurring opinion and detailing how the concurrence affirms, rather than deconstructs, the notion of African American deviance in families.
Gillner, Karl, Münstermann, Sebastian
core +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Lifestyle As Causes of Sexual Deviance In Islamic Perspective
, 2023 Salma Nuha Ghufron, Muhamad Arifin
openalex +2 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Pedagogia fenomenologica e interpretazione della devianza / Pédagogie phénoménologique et interprétation de la déviance / Phenomenological pedagogy and interpretation of deviance [PDF]
Rivista di Criminologia, Vittimologia e Sicurezza, 2010 Phenomenological pedagogy, introduced by Piero Bertolini in the second half of the past century, gets its fundamental and basic requirements from the phenomenology of Husserl, a German philosopher operating during the first years of 20th century.This ...
Cavana Laura
doaj