Results 131 to 140 of about 242,754 (286)

Skateboarding and the surplus value of city play

open access: yesFrontiers in Sports and Active Living
Cities, defined materially by concreted surfaces and geometrically shaped structures, have a novel ecology, a “grey space”. Grey spaces are criticized for their lack of salubrity in contrast to blue and green spaces enriched by natural biodiversity.
Brian Glenney   +2 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

RUSSIA AND CHINA: THE MAIN AREAS OF DEVIANCE AT THE BEGINNING OF THE XXI CENTURY

open access: yesВестник университета, 2019
The article analyses the main forms of deviance in modern Russia and in modern China. Found that media of deviant behavior, both in Russia and in China, are recruited from all segments of society.
S. Yanli, M. Romanenko
doaj  

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

open access: yesMolecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li   +10 more
wiley   +1 more source

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