Results 71 to 80 of about 122,135 (259)

Police Misconduct:Mapping its location, seriousness and theoretical underpinning [PDF]

, 2019
Police misconduct and the location of street crimes and deviance have received much research attention. The location of police misconduct, by contrast, has not.
Moss, Brian
core   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

MODELING LONGITUDINAL FLOOD DATA IN WEST SUMATRA USING THE GENERALIZED ESTIMATING EQUATION (GEE) APPROACH

Barekeng
Flooding is one of the many natural disasters that often hit Indonesia. In July 2023, three areas in West Sumatra experienced floods and landslides which caused damages and even 2 missing victims.
Alfi Nur Nitasari, Andini Sa'idah, Nurin Faizun, Kezia Eunike Darmawan, Marfa Audilla Fitri, Nur Chamidah   +5 more
doaj   +1 more source

Do cyber-birds flock together? Comparing deviance among social network members of cyber-dependent offenders and traditional offenders

, 2019
The distinct setting in which cyber-dependent crime takes place may reduce the similarity in the deviance of social network members. We test this assumption by analysing the deviance of the most important social contacts of cyber-dependent offenders and ...
Ruiter, S., Van Gelder, J., Weulen Kranenbarg, M.   +2 more
core   +2 more sources

Generalized Additive Models with Unknown Link Function Including Variable Selection [PDF]

, 2013
The generalized additive model is a well established and strong tool that allows to model smooth effects of predictors on the response. However, if the link function, which is typically chosen as the canonical link, is misspecified, substantial bias is ...
Petry, Sebastian, Tutz, Gerhard
core   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

The Co-Evolution of Test Maintenance and Code Maintenance through the lens of Fine-Grained Semantic Changes

, 2017
Automatic testing is a widely adopted technique for improving software quality. Software developers add, remove and update test methods and test classes as part of the software development process as well as during the evolution phase, following the ...
Levin, Stanislav, Yehudai, Amiram
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Bayesian comparison of latent variable models: Conditional vs marginal likelihoods

, 2019
Typical Bayesian methods for models with latent variables (or random effects) involve directly sampling the latent variables along with the model parameters.
Furr, D., Merkle, E. C., Rabe-Hesketh, S.   +2 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source