Results 171 to 180 of about 1,837 (213)

Lesion Site‐Targeted Microspheres Modulate Nav1.7‐Related Signaling for Osteoarthritis Treatment

open access: yesAdvanced Science, EarlyView.
Cartilage‐targeted carbamazepine‐loaded WYRGRL‐modified composite microspheres (CBZ/WCOM) anchor to exposed type II collagen in osteoarthritic lesions and release carbamazepine under acidic conditions. This bind‐then‐release platform modulates Nav1.7‐related sodium signaling, Na⁺/Ca²⁺ exchanger‐associated Ca2+ dynamics, and heat shock protein 70 ...
Cheng Chen   +15 more
wiley   +1 more source

CCL3 and IL‐7 Synergistically Enhance CAR‐T Efficacy in Solid Tumors

open access: yesAdvanced Science, EarlyView.
Synergistic delivery of CCL3 and IL‐7 by CAR‐T cells overcomes the immunosuppressive tumor microenvironment by enhancing cell infiltration, survival, and local immune reprogramming. This also establishes positive feedback that amplifies anti‐tumor activity and memory responses in both CAR‐T and endogenous T cells, presenting a robust therapeutic ...
Huanpeng Chen   +12 more
wiley   +1 more source
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Peer victimization, deviant peer affiliation and impulsivity: Predicting adolescent problem behaviors

Child Abuse and Neglect, 2016
Abundant evidence has demonstrated an association between peer victimization and adolescent problem behaviors. However, there is a large gap in knowledge about the potential mediators that associate peer victimization with problem behaviors and the potential moderators that exacerbate or buffer this association.
Jianjun Zhu   +2 more
exaly   +3 more sources

Peer Victimization and Substance Use in Early Adolescence: Influences of Deviant Peer Affiliation and Parental Knowledge

Journal of Child and Family Studies, 2016
Being the target of peer victimization contributes to alcohol and cigarette use during early adolescence. This 1-year longitudinal study extended the current literature by investigating the potential links between peer victimization and alcohol and cigarette initiation among a sample of 723 youths recruited from three middle schools in Southern China.
Yanping Jiang   +2 more
exaly   +2 more sources

Psychological security and deviant peer affiliation as mediators between teacher-student relationship and adolescent Internet addiction

Computers in Human Behavior, 2017
Abstract A growing body of research has documented that teacher-student relationship is negatively associated with adolescent Internet addiction. However, little is known about the mediating mechanisms underlying this relation. The present study investigated whether psychological security and deviant peer affiliation mediate the link between teacher ...
Jichao Jia, Xian Li, Yueyue Zhou
exaly   +2 more sources

Distrust Moderates the Effect of Deviant Peer Affiliation on Increased Externalizing in Adolescents

Journal of Youth and Adolescence, 2022
Deviant peer affiliation predicts externalizing behavior in adolescence, but no research explores how having negative or suspicious expectations of others (i.e., distrust) may evoke or buffer against the relationship between deviant peer affiliation and externalizing behavior.
Shou-An A. Chang, Arielle Baskin-Sommers
openaire   +2 more sources

Deviant peer affiliation, parent involvement, and aggressive behaviors of rural children in China

Journal of Research on Adolescence, 2022
AbstractAggressive behaviors in early childhood may indicate future violence, so effective intervention measures should be taken on time to promote children's physical and psychological health. Based on sampling survey data from Jintang County in Sichuan Province of China, this paper analyzes the mechanism of rural children's aggressive behaviors from ...
Yang, Yang, Binting, Deng, Fan, Yang
openaire   +2 more sources

Antisocial Behavior and Affiliation With Deviant Peers

Journal of Clinical Child & Adolescent Psychology, 2004
We examined the associations among gender, antisocial behavior, and peer-group affiliation in a high-risk sample of 401 homeless and matched housed adolescents (139 boys and 262 girls). The Diagnostic Interview Schedule for Children (Version 2.3, 1991; Costello, Edelbrock, Kalas, Kessler, & Klaric, 1982) yielded 2 measures of adolescent antisocial ...
Hillary J, Heinze   +2 more
openaire   +2 more sources

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