Results 71 to 80 of about 1,402,537 (260)

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Developmentally Sensitive Interaction Effects of Genes and the Social Environment on Total and Subcortical Brain Volumes.

PLoS ONE, 2016
Smaller total brain and subcortical volumes have been linked to psychopathology including attention-deficit/hyperactivity disorder (ADHD). Identifying mechanisms underlying these alterations, therefore, is of great importance. We investigated the role of
Jennifer S Richards, Alejandro Arias Vásquez, Barbara Franke, Pieter J Hoekstra, Dirk J Heslenfeld, Jaap Oosterlaan, Stephen V Faraone, Jan K Buitelaar, Catharina A Hartman   +8 more
doaj   +1 more source

The Longitudinal Interplay Between Social Network and Psychopathology in Multi-Problem Young Adult Men; Separating Within-and Between-Person Effects

Frontiers in Psychology, 2021
Young adulthood is characterized by many life changes. Especially for young men with problems across different life domains (i.e., multi-problem), these changes may entail obstacles.
Loïs Schenk, Miranda Sentse, Reshmi Marhe, Reshmi Marhe, Laura van Duin, Godfried Engbersen, Arne Popma, Sabine Severiens   +7 more
doaj   +1 more source

Alcohol abuse in Iranian adolescents: A mediational model of parental monitoring and affiliation with deviant peers

International Archives of Health Sciences, 2017
Aims: This study aimed to determine the attitudes toward alcohol abuse among students in Tehran and to develop and test a model of the relationships among parental monitoring and affiliation with deviant peers as they predict youth alcohol abuse. Materials and Methods: In this cross-sectional study, 1266 adolescents were recruited from high schools in ...
Sajad Aminimanesh, Javad Khodadadi Sangdeh, Khodabakhsh Ahmadi, Alimohammad Nazari, Mostafa Khanzade   +4 more
openaire   +2 more sources

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Relationships between emotional intelligence, parent-child relationship, deviant peer affiliation, and aggressive behavior among adolescents in Tehran, Iran [PDF]

, 2014
Aggression has considerably increased among adolescents in Iran. Recently, there has been growing attention on the effects of aggression on adolescents and their wellbeing.
Homauni, Masoumeh
core   +1 more source

Parental phubbing and mobile phone addiction among Chinese adolescents: a moderated mediation model

Frontiers in Psychology
It has been reported that parental phubbing is a significant predictor of mobile phone addiction (MPA) among adolescents. However, the mechanisms underlying this association remain largely unclarified.
Shutao Ma, Shutao Ma, Xiaoyan Bi, Hongbo Cui, Yankun Ma   +4 more
doaj   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Moderation of Harsh Parenting on Genetic and Environmental Contributions to Child and Adolescent Deviant Peer Affiliation: A Longitudinal Twin Study

, 2015
Affiliation with deviant peers is associated with biologically influenced personal attributes, and is itself a major contributor to growth in antisocial behavior over childhood and adolescence.
Li, Xinying, Li, Mengjiao, Chen, Jie, Deater-Deckard, Kirby   +3 more
core   +1 more source