From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Research on Submarine Cable Detection Systems of Remotely Operated Vehicles
Kongzhi Yu Xinxi JishuIn view of challenges faced when using remotely operated vehicles (ROVs) submarine cable laying, such as operational difficulty and low localization accuracy for cable detection, this paper introduces several common submarine cable detection systems ...
LIU Hairui +5 more
doaj
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Sensitivity of Responder Effects to Different Thresholds and Control Group Means on Patient-Reported Outcomes: Varying Group Standard Deviations. [PDF]
Pharm StatCappelleri JC, Ma J, Di Fusco M, Sun X.
europepmc +1 more source
Large-deviation analysis for counting statistics in mesoscopic transport
, 2011 We present an efficient approach, based on a number-conditioned master equation, for large-deviation analysis in mesoscopic transports. Beyond the conventional full-counting-statistics study, the large-deviation approach encodes complete information of ...
Liu Y +6 more
core
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Effect of Alveolar Ridge Inclination on Dynamic Navigation Accuracy of Implant Surgery: A Retrospective Clinical Study. [PDF]
Clin Cosmet Investig DentJiang X +6 more
europepmc +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
A tutorial on selecting, translating, and reporting variance priors in Bayesian multilevel models. [PDF]
Behav Res MethodsLiu L.
europepmc +1 more source