Results 201 to 210 of about 2,427,096 (265)

Age-inappropriate white matter injury reveals hidden cerebral small vessel disease burden and mortality risk. [PDF]

Cereb Circ Cogn Behav
Lee PL, Ou Yang WY, Chou KH, Lee WJ, Kuo CY, Lin SH, Chen LK, Lin CP, Chung CP.   +8 more
europepmc   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Augmented Reality-Assisted vs Manual Total Knee Arthroplasty: Clinical and Perioperative Outcomes in a Consecutive Single-Surgeon Cohort. [PDF]

Arthroplast Today
Farner N, Jawanda G, Santiago-Rivera OJ, Kassab SS.   +3 more
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Empirical Logic for Bio-Inspired Soft Computing: Illustrative Applications in Control Engineering and Cluster Analysis. [PDF]

Biomimetics (Basel)
Grotrian J.
europepmc   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Offset reconstruction in stemless and stemmed shoulder hemiarthroplasty: influence on long-term outcomes. [PDF]

Arch Orthop Trauma Surg
Trefzer R, Gurda A, Deisenhofer J, Weishorn J, Hariri M, Koch KA, Wolf M, Bülhoff M.   +7 more
europepmc   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Probing the diversity in dairy cattle reticulorumen temperature for adaptation selection. [PDF]

Sci Rep
Shirley AK, Thomson PC, Chlingaryan A, Clark CEF.   +3 more
europepmc   +1 more source

Stereopsis impairment and its association with fovea-disc angle in congenital superior oblique palsy patients with compensatory head posture: a cross-sectional study. [PDF]

Front Med (Lausanne)
Wei Y, Mao S, Lu W, Pan M, Chen A, Gao F, Chen S, Meng X, Shi X.   +8 more
europepmc   +1 more source