Results 81 to 90 of about 5,515,542 (307)
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Device-to-Device Communications Enabled Energy Efficient Multicast Scheduling in mmWave Small Cells
, 2017 To keep pace with the rapid growth of mobile traffic demands, dense deployment of small cells in millimeter wave (mmWave) bands has become a promising candidate for next generation wireless communication systems.
Chen, Xinlei +5 more
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
, 2018 Heterogeneous cellular networks (HCNs) with millimeter wave (mmWave) communications included are emerging as a promising candidate for the fifth generation mobile network.
Ai, Bo +4 more
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
, 2015 Device-to-Device (D2D) communications, which allow direct communication among mobile devices, have been proposed as an enabler of local services in 3GPP LTE-Advanced (LTE-A) cellular networks. This work investigates a hierarchical LTE-A network framework
Lu, Xiao, Niyato, Dusit, Wang, Ping
core +1 more source
Resource allocation scheme for D2D communication in mmWave 5G networks
Dianxin kexue, 2019 Since the combination of device-to-device (D2D) and mmWave technology can meet the needs of large-capacity, resource allocation was considered for D2D users in an outdoor millimeter wave scenario.
Bing YI, Yongli CHEN, Ruixue ZHAO
doaj +2 more sources
Outage Analysis of Device-to-Device Communication System
Vìsnik Nacìonalʹnogo Tehnìčnogo Unìversitetu Ukraïni Kììvsʹkij Polìtehnìčnij Ìnstitut: Serìâ Radìotehnìka, Radìoaparatobuduvannâ, 2018 In this paper, we analyze the outage performance of Device-to-Device (D2D) communication system in the presence of co-channel interference (CCI). Gamma distribution is considered here to model the random channel gain powers of D2D communication system ...
Z. Hussain +3 more
doaj +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source