Results 81 to 90 of about 2,058,154 (316)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
An Analysis of the Problems Impeding the Ground Operations in the Air Freight Industry
, 1970 In the days when air transportation couldn't really be called an industry, air freight took a poor third place to passenger and mail operations. As a rule, only the residual space on passenger aircraft was made available for freight, effectively ...
Device, Michael A.
core
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Device-to-Device Communication in 5G: Towards Efficient Scheduling
, 2018 5G wireless networks are expected to carry large traffic volumes due to the growth of mobile devices and the increasing demand for high data rates from applications.
Raad Raad (19584145) +3 more
core
Performance analysis of device-to-device communications underlaying cellular networks
, 2015 Device-to-device (D2D) communications underlaying cellular networks are considered to be promising communication modes to improve network radio resource efficiency and provide higher transmission data rates to devices close to each other.
Xiang, Wei +4 more
core +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Mobile Device Management Policy
, 2023 The use of mobile devices in the workplace has grown significantly over the years. Most adults do not leave home without their phones, laptops, tablets, or other portable media devices.
Meadows, Sydney +1 more
core
Device Fingerprinting and Identification
, 2023 : Browsers are our portal to the web, and if users want a secure, adequate and smart services, websites need to know some information about their browser, operating system and their hardware device.
Omar Khalid Alfaraj
core +1 more source
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source