Results 101 to 110 of about 12,443 (217)

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source

Crystal structure of MutYX: a novel clusterless adenine DNA glycosylase with a distinct C-terminal domain and 8-oxoguanine recognition sphere. [PDF]

Nucleic Acids Res
Trasviña-Arenas CH, Hashemian M, Malek M, Merrill S, Fisher AJ, David SS.   +5 more
europepmc   +1 more source

Testing functional hypotheses about cross-cultural variation: A maximum-likelihood comparative analysis of Indo-European marriage practices [PDF]

, 2009
Fortunato, L, Mace, R
core  

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

Advanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore, Andrea Basile, Stefano Freddi, Irene Schiano Lomoriello, Carlo Ribelle Zucca, Giuseppe Ciossani, Luigi Scietti, Alessandro Cuomo, Simona Ronzoni, Simone Pelicci, Mario Faretta, Elena Zaccheroni, Giuliana Pelicci, Vittoria Matafora, Angela Bachi, Rosalind Helen Gunby, Salvatore Pece, Sara Sigismund, Letizia Lanzetti, Ivan Nicola Colaluca, Pier Paolo Di Fiore   +20 more
wiley   +1 more source

Who Decides What Is Prebiotically Plausible? The Risks of Premature Constraints in Origin-of-Life Research. [PDF]

Life (Basel)
Eiby SHJ, Hassenkam T.
europepmc   +1 more source

Progress towards achieving child survival goals in Kenya after devolution: Geospatial analysis with scenario-based projections, 2015-2025. [PDF]

PLOS Glob Public Health, 2022
Joseph NK, Macharia PM, Okiro EA.
europepmc   +1 more source

Book reviews [PDF]

Teaching/Communication/Extension/Profession,
Eckersley, Peter, Mallawaarachchi, Thilak, Marshall, Graham R., McLaren, Donald, Musgrave, Warren F., Pannell, David J., Schilizzi, Steven, Watson, Alistair S.   +7 more
core   +1 more source

Conformable Microelectrode Arrays Integrated with a Scoop‐Shaped Slide‐Well for Dynamic Electrophysiological Profiling of Patient‐Derived Cardiac Organoids

Advanced Science, EarlyView.
A flexible, ultrathin multi‐channel microelectrode array (MEA) conformally integrated onto a curved slide‐well enables stable electrical interfacing with 3D cardiac organoids. The geometry‐guided self‐alignment allows simultaneous recording of extracellular field potentials and contractile motion from irregular, beating tissues.
Ye Seul Kim, Jeonghwa Jeong, Gyeonghwa Heo, Young Woo Kwon, Jeongha Lee, Yoon Ji Jeong, Gyu Tae Park, Seongdo Jeong, Ki Won Hwang, Murim Choi, Jinhong Shin, Suck Won Hong, Jae Ho Kim   +12 more
wiley   +1 more source

Climate and health governance: Opportunities and challenges addressing extreme heat in the United States. [PDF]

J Clim Chang Health
Ring NL, Daley DM, Brunsell NA.
europepmc   +1 more source

Teacher education in transition: the changing landscape across the UK [PDF]

, 2011
Murray, Jean (ed.), Wishart, Jocelyn (ed.)   +1 more
core