Results 171 to 180 of about 250,188 (305)

Discovery of CRBN‐based molecular glue degraders targeting WIZ transcription factor

Bulletin of the Korean Chemical Society, EarlyView.
This work reports the discovery of 9l, a novel cereblon‐based molecular glue degrader which targets the WIZ transcription factor. Compound 9l facilitates WIZ‐CRBN ternary complex formation to degrade WIZ, subsequently inducing γ‐globin expression in HUDEP‐2 cells and highlighting its potential as a sickle cell disease therapy.
Tae‐Jun Kim, Seongu Seong, Jung‐Ae Kim, Taeyeon Kwon, Hyun Jin Kim, Jeong‐Hoon Kim, Jong Yeon Hwang, Jin Hwa Cho, Kyoungmin Choi   +8 more
wiley   +1 more source

Pharmacokinetics of Dexamethasone in Tuberculous Meningitis. [PDF]

Clin Infect Dis
Calderin JM, Resendiz-Galvan JE, Abdelgawad N, Davis A, Stek C, Wiesner L, Meintjes G, Wilkinson RJ, Denti P, Wasserman S.   +9 more
europepmc   +1 more source

High drug payload nanoparticles formed from dexamethasone-peptide conjugates for the treatment of endotoxin-induced uveitis in rabbit

, 2019
Xinxin Yu, Renshu Zhang, Lei Lei, Qianqian Song, Xingyi Li Institute of Biomedical Engineering, School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou 325027, People’s Republic of China Purpose: To develop and
Li X, Lei L, Song Q, Zhang R, Yu X
core  

Nano‐networks via reaction‐induced self‐assembly coordinate spatiotemporal multi‐drug delivery for acute kidney injury therapy

BMEMat, EarlyView.
Multifunctional nano‐networks (NNWs) are prepared via reaction‐induced self‐assembly (RISA) of spermidine (SPD), epigallocatechin gallate (EGCG), 2‐formylphenylboronic acid (2‐FPBA), and deferoxamine (DFO) through dynamic iminoboronate bonds. These NNWs leverage the oxidative AKI microenvironment to trigger disintegration, enabling site‐specific ...
Juan Jin, Xiao Zhang, Chenxi Wang, Taian Jin, Xinyang Fang, Yixuan Gao, Mengchun Chen, Weiyang Meng, Chang Gao, Wenlu Li, Yuanfeng Li, Yijie Chen, Calvin A. Omolo, Thirumala Govender, Linqi Shi, Yunguang Wang, Yong Liu, Qiang He   +17 more
wiley   +1 more source

Dexamethasone implantation in birdshot chorioretinopathy – long-term outcome

, 2018
Asima Bajwa,1 Travis Peck,1 Ashvini K Reddy,2 Peter A Netland,1 Yevgeniy Shildkrot1 1Department of Ophthalmology, University of Virginia, Charlottesville, VA, USA; 2Johns Hopkins Wilmer Eye Institute, Baltimore, MD, USA Purpose: To evaluate the long-term
Peck T, Netland PA, Reddy AK, Bajwa A, Shildkrot Y   +4 more
core  

Advanced nanotherapeutics for combating ocular infections: Rational design, antimicrobial mechanisms, and therapeutic breakthroughs

BMEMat, EarlyView.
Nanomaterials revolutionize ocular infection treatment by enabling targeted drug delivery and enhanced antimicrobial efficacy against resistant pathogens. This review systematically explores their rational design, multimodal mechanisms, and translational potential for next‐generation anti‐infective therapies.
Yujia Liu, Xuetian Wen, Yue Tan, Rui Zeng, Yijuan Zhang, Tong Lin, Lan Gong, Zichao Luo   +7 more
wiley   +1 more source

Role of articaine and perineural dexamethasone in prolonging postoperative analgesia in mandibular third molar surgery: A comparative analysis. [PDF]

Med Oral Patol Oral Cir Bucal
Şitilci AT, Atalay B, Kuşlu T, Onur ÖD.   +3 more
europepmc   +1 more source

Management of severe bone loss in patients at risk of medication‐related osteonecrosis of the jaw with microsurgery and guided bone regeneration: A case study

Clinical Advances in Periodontics, EarlyView.
Abstract Background Medication‐related osteonecrosis of the jaw (MRONJ) is a challenging complication associated with antiresorptive medications. Its exact pathophysiology remains unclear, but dental extractions and infections are known triggers, complicating prevention, and treatment.
Pedro Franco Ferreira, José Maurício Paradella de Camargo, Lara Maria Alencar Ramos Innocentini, Ana Carolina Fragoso Motta   +3 more
wiley   +1 more source

Perineural Dexamethasone Versus Intravenous Dexamethasone as an Adjunct to Local Anaesthetic Mixture in Supraclavicular Brachial Plexus Block: A Prospective Double-Blind Randomized Controlled Study. [PDF]

Cureus
Ninan LG, Dhamotharan S, Kamalnath A, Segaran S.   +3 more
europepmc   +1 more source

Flap perfusion of superficial split flap design for guided bone regeneration: A case report with ultrasonography

Clinical Advances in Periodontics, EarlyView.
Abstract Background Effective flap management is crucial for successful bone regeneration procedures. Traditional flap release has been performed by the deep split design; recently, the superficial split design revives for its proposed anatomical and biomechanical advantages.
Oscar Durán‐Garnica, Karen Villarreal‐Arizpe, Amanda Rodríguez, Oliver Kripfgans, Hsun‐Liang Chan   +4 more
wiley   +1 more source