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Bioavailability of dexamethasone; II. Dexamethasone phosphate

Clinical Pharmacology & Therapeutics, 1975
Plasma levels of dexamethasone phosphate (DP) and dexamethasone free alcohol (DA) were determined by a modification of existing radioimmunoassay methodology following intravenous administration of DP in man. Areas under DA plasma profiles were a linear function of DP dosage over the 40‐fold range 0.05 to 2.0 mg/kg, and, by comparison with values ...
L E, Hare   +4 more
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Dexamethasone in Dermatology

Archives of Dermatology, 1959
Dexamethasone is 9-α-fluoro,16-α-methylprednisolone. * It is one of a group of prednisolone analogues synthesized and studied by Arth and his co-workers 1,2 in the continuing search for modifications of hydrocortisone which would afford increased anti-inflammatory and antiallergic activity but would produce minimal mineral imbalance and the other ...
N B, KANOF, S, BLAU
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Dexamethasone and Osteonecrosis

Australian and New Zealand Journal of Medicine, 1981
Abstract: Four cases are reported in whom osteonecrosis followed after Dexamethasone was administered in high dosage for a short time to mduce cerebral and spinal cord oedema. Although corticosteroids have been implicated in the development of osteonecrosis, the delay from corticosteroid administration to the development of symptoms (9–30 months ...
K A, Black, M S, Khangure, E T, Owen
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Dexamethasone in adenotonsillectomy

International Journal of Pediatric Otorhinolaryngology, 1996
Edema contributes substantially to the postoperative discomfort and morbidity of adenotonsillectomy. In a double-blind study, 58 children undergoing adenotonsillectomy were given a single intraoperative dose of either dexamethasone or saline. The steroid markedly affected the postoperative course in the first day after surgery.
L W, Tom   +3 more
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The dexamethasone suppression test: Importance of dexamethasone concentrations

Biological Psychiatry, 1987
Plasma dexamethasone concentrations and cortisol response to dexamethasone were measured in 29 normal healthy volunteers, 23 depressed patients, and 10 patients with anorexia nervosa at 4:00 PM postdexamethasone. In each of the 3 groups, nonsuppressors had lower dexamethasone concentrations than suppressors. Of the subjects with plasma dexamethasone at
K P, Maguire   +4 more
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Perioperatives Dexamethason

Der Anaesthesist, 2019
Dexamethasone is a synthetic steroid that has been used for many years in the clinical routine due to its anti-inflammatory, anti-allergic and immunosuppressive properties. Furthermore, dexamethasone has been used for a long time for prophylaxis and treatment of chemotherapy-induced nausea and vomiting.
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Plasma dexamethasone concentrations and the dexamethasone suppression test

Biological Psychiatry, 1990
Altered bioavailability or altered pharmacokinetics of dexamethasone (dex) may contribute to a positive Dexamethasone Suppression Test (DST) in psychiatric patients. We measured plasma dex and plasma cortisol concentrations in 32 patients with primary major depressive disorder (MDD), 14 patients with other psychiatric disorders, and 16 normal controls.
James C. Ritchie   +5 more
openaire   +2 more sources

Dexamethasone

Reactions Weekly, 2022
Muhammad Riaz   +11 more
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