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Heparin cofactor II is degraded by heparan sulfate and dextran sulfate

Biochemical and Biophysical Research Communications, 2015
Heparan sulfate normally binds to heparin cofactor II and modulates the coagulation pathway by inhibiting thrombin. However, when human heparin cofactor II was incubated with heparan sulfate, heparin cofactor II became degraded. Other glycosaminoglycans were tested, including hyaluronic acid, chondroitin sulfates, dermatan sulfate, and heparin, but ...
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Mapping the dextran sulfate binding site on CD2

Immunology & Cell Biology, 1990
SummaryThis study has analysed the binding of a series of anti‐CD2 monoclonal antibodies (MoAbs) to T cells in the presence of the sulfated polysaccharide dextran sulfate (2·3 sulfates/monosaccharide, 500 kDa) (DXS) to define the DXS binding site on CD2. The results show that DXS interacts primarily at the T112 epitope.
H S, Warren, C R, Parish
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Dextran Sulfate Sodium-Induced Colitis in Immunodeficient Rats

Digestive Diseases and Sciences, 2000
To examine the morphology of colitis and study the role of the immune system in colitis, we compared colitis in immunocompetent Wistar-Kyoto rats with that in spontaneously hypertensive rats, known to have T-cell dysfunction. Rats were treated with 3% dextran sulfate in drinking water for periods ranging from 3 to 60 days.
K, Shichijo   +3 more
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Dextran-sulfate cellulose adsorption for lowering Lp[a]

Chemistry and Physics of Lipids, 1994
Dextran sulfate selectively adsorbs lipoproteins that contain apolipoprotein-B100, including those associated with apolipoprotein-a, from human plasma with high affinity. Dextran sulfate immobilized on cellulose is incorporated into the Liposorber LA-15 system (Kaneka Corporation, Osaka, Japan).
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Dextran Sulfate

2007
S.J. Enna, David B. Bylund
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Dextran sulfate

The American Journal of Surgery, 1967
William A. Barnes   +3 more
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Bisoprolol/dextran sulfate

Reactions Weekly, 2020
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Distribution of Sulfate Groups in the Partially Sulfated Dextrans

The Journal of Biochemistry, 1973
H, Miyaji, A, Misaki
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