Results 171 to 180 of about 12,421 (291)

Restores Aβ Clearance by Overcoming PCSK9–LRP1 Dysregulation and TRIB3‐Mediated Autophagy Blockade in Alzheimer's Disease

Advanced Science, EarlyView.
PCSK9 upregulation in cerebrovascular endothelial cells and microglia destabilizes the Aβ transporter LRP1, while TRIB3‐associated autophagy blockade further limits intracellular Aβ degradation. A RAP‐modified tea‐polyphenol nanoparticle co‐delivers siPCSK9 and siTRIB3 to restore LRP1‐mediated Aβ efflux and autophagy‐dependent degradation, reducing Aβ ...
Jie Miao, Jing Wang, Yankun Li, Haipei Zhang, Yanli Zhang, Qingnian Li, Bo Xiao, Wenhu Zhou, Junhong Guo   +8 more
wiley   +1 more source

Structural Bases for the Unconventional Activity of a Viroporin Channel. [PDF]

Biochemistry
Wiley B, Largo E, Nabais L, Nieva JL, Domene C.   +4 more
europepmc   +1 more source

Degrading GPX4 via Biomimetic Nanoparticle‐Mediated In Situ Synthesis of Deep‐Learning‐Designed Binder‐Degron Chimeras for Prostate Cancer Therapy

Advanced Science, EarlyView.
A deep‐learning‐designed binder is fused to a combinatorial degron to create a binder‐degron chimera (bdC) that recruits the CUL2‐RING ubiquitin ligase complex. Encapsulation in a prostate‐cancer‐targeted, CD47‐camouflaged nanocarrier enables tumor‐specific in situ bdC expression, triggering GPX4 degradation and ferroptosis, thereby establishing a ...
Si‐Han Zhang, Ye An, Na Zeng, Mei‐Cheng Liu, Jian‐Xuan Sun, Xi Gong, Jin‐Zhou Xu, Shao‐Gang Wang, Qi‐Dong Xia   +8 more
wiley   +1 more source

Reply to Dey and Schreiber: Porous media framework of intracellular diffusion is not limited to inert molecules. [PDF]

Proc Natl Acad Sci U S A
Destrian O, Mège RM, Ladoux B, Goyeau B, Chabanon M.   +4 more
europepmc   +1 more source

Non‐Coding Transcripts From Diversified Members of IgLec Family Protect Antiviral Effectors From Viral miRNA

Advanced Science, EarlyView.
The IgLec gene family generates both protein‐coding antiviral effectors and non‐coding transcripts. Upon viral infection, non‐coding transcripts are preferentially targeted by viral miR‐N48, thereby buffering protein‐coding isoforms from repression. Depletion of these decoy transcripts compromises antiviral defense, revealing a non‐coding RNA‐mediated ...
Ying Huang, Rui Shen, Xin Huang, Gu‐Qin Ji, Jiang‐Feng Lan, Qian Ren   +5 more
wiley   +1 more source

Aberrant activation of renal functional reserve and reduced tubule flow, but not obstruction, is associated with cystogenesis in <i>Pkd2</i> mutant kidneys. [PDF]

Function (Oxf)
Thomas IN, Rajendran S, Li Z, Haycraft CJ, Croyle MJ, Yoder BK.   +5 more
europepmc   +1 more source

In Situ Photo‑Crosslinked Functional Bilayer Hydrogel Modulates Local Microenvironment and Remyelination After Optic Nerve Injury

Advanced Science, EarlyView.
A blue‐light‐crosslinked bilayer hydrogel was developed for local optic nerve repair. The adhesive GM‐Odex outer layer seals and anchors the lesion, while the non‐adhesive GM‐imid inner layer releases MPDA‐Cle without obstructing CSF flow. This system modulates oxidative and inflammatory microenvironments, supports oligodendrocyte differentiation and ...
Tonghe Pan, Yate Huang, Junhao Zhang, Shudong Tian, Zhixing Li, Xuanwen Li, Yanchen Zhang, Dongmei Wang, Sihao Ye, Ming Jin, Neng Ling, Wentao Yan, Kaihui Nan, Wencan Wu   +13 more
wiley   +1 more source

Multivalent Antibody-Recruiting Molecules for Targeted Immune-Killing of Carbonic Anhydrase IX-Expressing Cancer Cells. [PDF]

Angew Chem Int Ed Engl
Peng H, De Baere J, Cappellesso F, English K, Deswarte K, Laoui D, Lambrecht BN, De Geest BG, Louage B.   +8 more
europepmc   +1 more source

Sonogenetic Control of Engineered Probiotics for the Treatment of MASH by Modulating the Gut‐Liver Axis

Advanced Science, EarlyView.
Researchers developed an engineered probiotic encapsulated in an inulin hydrogel, enabling ultrasound‐triggered intestinal delivery of IL‐22. In MASH model mice, this system remodeled gut microbiota, strengthened the intestinal barrier and reduced portal LPS and hepatic IL‐6.
Chunya Ji, Yan Fang, Shen Zhang, Weichen Xu, Wenyun Guo, Jing Chen, Mingrui Zhu, Congjian Wen, Siming Chen, Yuli Zhu, Huixiong Xu, Haohao Yin   +11 more
wiley   +1 more source

Early Gut-Vascular Barrier Breakdown Precedes Colitis Onset in Murine Models. [PDF]

Cell Mol Gastroenterol Hepatol
Mohamed Abdou M, Kreiß L, Schmid B, Thoma OM, Krüger R, Bénard A, Müller TM, Knauss A, Gabel M, González-Acera M, Lyu Y, Petter K, Lindemann A, Saad MSA, Eichhorn P, Becker C, Naschberger E, Zundler S, Weigmann B, Rath T, Atreya R, Kühl AA, Trajanoski Z, TRR241 IBDome Consortium, Friedrich O, Waldner MJ, Neurath MF, Herrmann M, Schürmann S, Britzen-Laurent N, Stürzl M.   +30 more
europepmc   +1 more source