Results 61 to 70 of about 79 (76)

Biphenyl amide p38 kinase inhibitors 4: DFG-in and DFG-out binding modes

Bioorganic and Medicinal Chemistry Letters, 2008
Paul Bamborough
exaly  

Structure-based drug design enables conversion of a DFG-in binding CSF-1R kinase inhibitor to a DFG-out binding mode

Bioorganic and Medicinal Chemistry Letters, 2010
Marvin J Meyers
exaly  

An SFG/DFG investigation of CN− adsorption at an Au electrode in 1-butyl-1-methyl-pyrrolidinium bis(trifluoromethylsulfonyl) amide ionic liquid

Electrochemistry Communications, 2010
Benedetto Bozzini, Andreas Bund, Bertrand Busson   +2 more
exaly  

Structural Characterization of the Aurora Kinase B “DFG-flip” Using Metadynamics

AAPS Journal, 2019
Naga Rajiv Lakkaniga, meenakshisundaram Balasubramaniam, Brendan Frett   +2 more
exaly  

The dynamic switch mechanism that leads to activation of LRRK2 is embedded in the DFGψ motif in the kinase domain

Proceedings of the National Academy of Sciences of the United States of America, 2019
Sven H Schmidt, Matthias J Knape, Daniela Boassa   +2 more
exaly  

Protein Kinase Inhibitor Design by Targeting the Asp-Phe-Gly (DFG) Motif: The Role of the DFG Motif in the Design of Epidermal Growth Factor Receptor Inhibitors

Journal of Medicinal Chemistry, 2013
Mohane S Coumar, Wen-Hsing Lin, Hsing-Pang Hsieh   +2 more
exaly  

Conformational Analysis of the DFG-Out Kinase Motif and Biochemical Profiling of Structurally Validated Type II Inhibitors

Journal of Medicinal Chemistry, 2015
Jeffrey R Peterson, Peng He, Vivek Modi
exaly  

A Novel Mechanism by Which Small Molecule Inhibitors Induce the DFG Flip in Aurora A

ACS Chemical Biology, 2012
Jin-Yi Zhu, Ernst Schonbrunn
exaly  

Sorafenib inhibits p38α activity in colorectal cancer cells and synergizes with the DFG-in inhibitor SB202190 to increase apoptotic response

Cancer Biology and Therapy, 2012
Valentina Grossi, Giuseppe Ingravallo, Alberto Del Rio   +2 more
exaly  

Ins and Outs of Kinase DFG Motifs

Chemistry and Biology, 2013
Neil Shah
exaly