Results 121 to 130 of about 95,310 (311)

Neuid: A Novel Neuron‐Enriched LncRNA that Connects Epigenetic Gene Silencing to Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
ABSTRACT The increasing evidence that non‐coding RNAs can become deregulated during pathogenesis is dramatically expanding the space for drug discovery beyond the protein‐coding genome. Long noncoding RNAs (lncRNAs) are emerging as key regulators of cellular function, yet most remain uncharacterized.
Ranjit Pradhan   +17 more
wiley   +1 more source

PIDE/DGS

open access: yesCordis: Revista Eletrônica de História Social da Cidade
O presente artigo é fruto de uma pesquisa feita em meu TCC da Licenciatura em História, e que se desenvolve desde 2017. Nela, é analisada a repressão política e social da PIDE/DGS no pós-Segunda Guerra Mundial, entre 1945 e 1974, nas vigências dos governos de António de Oliveira Salazar (1932-1968) e no de Marcello Caetano (1968-1974).
William Valdujo Tavares Vieira Morgado   +1 more
openaire   +1 more source

Accuracy-based scoring for DOT: towards direct error minimization for data-oriented translation [PDF]

open access: yes, 2009
In this work we present a novel technique to rescore fragments in the Data-Oriented Translation model based on their contribution to translation accuracy.
Galron, Daniel   +3 more
core   +4 more sources

SR‐B1‐Mediated Transplacental Transfer of Hydrophobic Toxicants Disrupts Fetal Development During Barriergenesis

open access: yesAdvanced Science, EarlyView.
This study maps the spatiotemporal distribution of hydrophobic toxicants and endogenous metabolites in the developing placenta and fetus. By integrating mass spectrometry imaging with snRNA‐seq, we identify SR‐B1 as a key transporter driving early‐gestation xenobiotic transfer and reveal a critical exposure window associated with persistent fetal ...
Yixuan Huang   +10 more
wiley   +1 more source

Alkylthienyl Side Groups in Conjugated Polymers Enable Localization of π Electron Density and Facilitate Efficient Hole Transfer

open access: yesAdvanced Science, EarlyView.
Resonance Raman spectroscopy is used in combination with other spectroscopic and morphology characterization techniques to unveil the mechanistic origin of the shift in synthetic strategy to alkylthienyl peripheral groups for high‐performing organic photovoltaics.
Hristo Ivov Gonev   +13 more
wiley   +1 more source

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism

open access: yesAdvanced Science, EarlyView.
The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying   +8 more
wiley   +1 more source

3D Bioprinted Fat‐Myocardium Model Unravels the Role of Adipocyte Hypertrophy in Atrial Dysfunction

open access: yesAdvanced Science, EarlyView.
A human‐derived 3D bioprinted fat–myocardium model is developed to investigate how adipocyte hypertrophy drives atrial dysfunction in obesity. Palmitate‐induced adipocyte hypertrophy promotes adipose dysfunction that impairs atrial cardiomyocyte metabolism and electrophysiology through both paracrine and direct interactions. This platform recapitulates
Lara Ece Celebi, Pinar Zorlutuna
wiley   +1 more source

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