Results 151 to 160 of about 39,824 (247)
Asia Pacific Viewpoint, EarlyView.ABSTRACT Scholars working on conflict and violence often engage with local organisations, yet the methodological and ethical implications of volunteering‐while‐researching are rarely discussed in writing. This article contributes to debates on decolonizing research by conceptualising volunteering‐while‐researching as a practice that—while imbued with ...
Shona Loong
wiley +1 more source
Targeting the NR3C1‐ACSL4 Axis Triggers Ferroptosis to Overcome Radioresistance in Prostate Cancer
Cancer Science, EarlyView.The glucocorticoid receptor NR3C1 drives prostate cancer radioresistance by upregulating ACSL4. High ACSL4 levels create a lipid metabolic vulnerability. The clinical agent DHA synergizes with ACSL4 to induce lipid peroxidation and ferroptosis, effectively overcoming radioresistance.
Jing Yang +7 more
wiley +1 more source
DHA retroconversion revisited: dietary DHA spares endogenous EPA [PDF]
The American Journal of Clinical Nutrition, 2019 openaire +2 more sources
EPHX2 Loss Promotes CRC Migration via EET‐Dependent Chemokine Elevation and Mitochondrial Defect
Cancer Science, EarlyView.Loss of EPHX2 promotes EET accumulation, which in turn enhances CXCL and ROS production, thereby promoting the migratory and invasive abilities of CRC cells. ABSTRACT Epoxide hydrolase 2 (EPHX2) is a key enzyme in fatty acid metabolism that metabolizes epoxyeicosatrienoic acids (EETs), lipid mediators involved in inflammation, angiogenesis, and ...
Jianjun Zhu +10 more
wiley +1 more source
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Diabetes mellitus (DM) and chronic kidney disease (CKD) frequently coexist and together create a ‘triple threat’ with dyslipidaemia, enhancing the risk for cardiovascular morbidity and mortality. Diabetic kidney disease (DKD) leads to altered lipid metabolism through insulin resistance, inflammation and oxidative stress resulting in an ...
Ann S. Forrest +3 more
wiley +1 more source
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Aims White adipose tissue (WAT) innervation by sensory and sympathetic axons contributes to tissue functions, but the consequences of selectively disrupting sympathetic input to WAT remain incompletely defined. Materials and Methods We utilised 6‐hydroxydopamine (6‐OHDA) as a validated approach to achieve bilateral sympathetic denervation of ...
Gilian Gunsch +15 more
wiley +1 more source
Dental Traumatology, EarlyView.ABSTRACT Background/Aim Traumatic dental injuries (TDIs) are a common occurrence in children. They vary in their severity, management can be complex, and various settings may be accessed by families for management. The care pathway to manage TDIs in children varies across the UK, with little understanding of these pathways and the impact they have on ...
Nathalie Gallichan +4 more
wiley +1 more source
European Journal of Dental Education, EarlyView.ABSTRACT Purpose Effective communication and empathy are core competencies in patient‐centred dental care. However, structured training in these skills is often limited in dental curricula. This study explored the association between a structured communication and body language course and dental students awareness of nonverbal communication, empathy ...
Serhat Efeoglu +4 more
wiley +1 more source
The FEBS Journal, EarlyView.Using 1H NMR metabolomics, we measured polar and lipid metabolites from human blood neutrophils from people with frailty (n = 31, mean age 84Y), people with rheumatoid arthritis (n = 16, mean age 55Y), robust older (n = 24, mean age 66Y) and healthy younger people (n = 21, mean age 22Y).
Genna Ali Abdullah +5 more
wiley +1 more source
The FEBS Journal, EarlyView.Circadian disruption via constant light induces sex‐specific remodeling of the microbiome, lipid mediators, and immune responses. Females exhibit broader gut microbiota alterations, reduced jejunal oxylipins, increased hypothalamic N‐acylethanolamines, and a more inflammatory cytokine profile. Muscle responses are sex‐ and fiber type‐dependent: females
Pejman A. Pashaki +7 more
wiley +1 more source