Results 11 to 20 of about 17,491 (180)
Steroid Recognition in Adhesion GPCRs: A Structural and Pharmacological Perspective. [PDF]
Pharmacol Res PerspectABSTRACT Emerging evidence suggests steroids may act as generalizable ligands for adhesion GPCRs, a receptor class with considerable pharmacological potential. While most studies have focused on the ADGR‘G' subfamily, recent cryo‐EM structures of the androgens 5α‐dihydrotestosterone (5α‐DHT) and methenolone bound to ADGRD1 revealed a putative steroid ...
Fleming B +4 more
europepmc +2 more sources
Association between prenatal androgens and cord blood androgens, a path analysis
Scientific Reports, 2023 To determine association paths between prenatal androgens and cord blood androgens. The concentrations of T, FT, DHT, DHEA and SHBG in prenatal venous blood and cord blood were measured in 342 pregnant women and their neonates.
Hui Xu +9 more
doaj +1 more source
Frontiers in Pharmacology, 2021 The abnormal activation of the NLRP3 inflammasome is closely related to the occurrence and development of many inflammatory diseases. Targeting the NLRP3 inflammasome has been considered an efficient therapy to treat infections.
Ziying Wei +27 more
doaj +1 more source
Development of DHT-receptor (DHT-R) estimation through (3H)-DHT exchange [PDF]
Pediatric Research, 1981 The convenient dihydrotestosterone-(DHT)-R estimation with (3H)-methyltrienolone (R1881)in human tissue is unspecific as it is also bound by the progestin receptors. We have, therefore, developed a highly specific (3H)-DHT exchange assay for cytoplasmic and nuclear DHT-R.
H Moeller, G Oettling, D Gupta
openaire +1 more source
Sex hormone-binding globulin, androgens and mortality: the KORA-F4 cohort study
Endocrine Connections, 2020 Objective: Sex hormone-binding globulin (SHBG) and androgens have been associated with mortality in women and men, but controversy still exists. Our objective was to investigate associations of SHBG and androgens with all-cause a nd cause-specific ...
Florian Schederecker +8 more
doaj +1 more source
Synthesis of a Single Benzene-Based Fluorophore for Selective Recognition of Al Ions
Chemosensors, 2022 Though 2,5-dihydroxyterephthalic acid (DHT) is composed of a single benzene molecule, it is blue-emissive in common organic solvents and in the solid state.
Yena Lee +4 more
doaj +1 more source
A novel PCOS rat model and an evaluation of its reproductive, metabolic, and behavioral phenotypes
Reproductive Medicine and Biology, 2022 Background Although animal models of PCOS have been used in many studies, none of them can reproduce both the reproductive and metabolic phenotypes of PCOS. In addition, behavioral parameters have not been evaluated in PCOS animal models.
Shuhei Kamada +15 more
doaj +1 more source
Journal of Biomedical Science, 2022 Background Androgenetic alopecia (AGA) is a genetic disorder caused by dihydrotestosterone (DHT), accompanied by the senescence of androgen-sensitive dermal papilla cells (DPCs) located in the base of hair follicles.
Young Hyun Jung +10 more
doaj +1 more source
Proceedings of the 2008 ACM CoNEXT Conference on - CONEXT '08, 2008 Recent activities in the IRTF (Internet Research Task Force), and in particular in the Routing Research Group (RRG), focus on defining a new Internet architecture, in order to solve scalability issues related to interdomain routing. The research community has agreed that the separation of the end-systems' addressing space (the identifiers) and the ...
Mathy, Laurent, Iannone, Luigi
openaire +4 more sources
Impact of One-Week Administration of Dihydrotestosterone in Rat Anterior Pituitary Gland
International Journal of Endocrinology, 2022 Hyperandrogenism causes dysfunction of the hypothalamic–pituitary–gonadal (HPG) axis in reproductive women. In this study, we examined the effects of dihydrotestosterone (DHT) on characteristic changes in rat anterior pituitary gland samples.
Haruhiko Kanasaki +6 more
doaj +1 more source