Results 31 to 40 of about 17,491 (180)
Frontiers in Cell and Developmental Biology, 2021 Hyperandrogenism is a key pathological feature of polycystic ovarian syndrome (PCOS). Excess androgen can lead to PCOS-like cell hypertrophy in the ovaries and adipose tissue of rodents.
Li-Feng Sun +15 more
doaj +1 more source
5-alpha-dihydrotestosterone elevations associated with phentermine use
Therapeutic Advances in Endocrinology and Metabolism, 2018 Background: A case of 5-alpha-dihydrotestosterone (DHT) elevation associated with phentermine initiation is reported, and possible mechanisms are discussed. There are no published reports of this association in the literature.
Scott M. Pearson +2 more
doaj +1 more source
iEquol an isoflavonoid: potential for improved prostate health,
Reproductive Biology and Endocrinology, 2011 Background To determine: in vitro binding affinity of equol for 5alpha-dihydrotestosterone (5alpha-DHT), in vitro effects of equol treatment in human prostate cancer (LNCap) cells, and in vivo effects of equol on rat prostate weight and circulating ...
Hamaker Amy N +4 more
doaj +1 more source
Spurring Adoption of DHTs with OpenHash, a Public DHT Service [PDF]
, 2005 The past three years have seen intense research into Distributed Hash Tables (DHTs): both into algorithms for building them, and into applications built atop them. These applications have spanned a strikingly wide range, including file systems [1–3], event notification [4], content distribution [5], e-mail delivery [6], indirection services [7,8], web ...
Brad Karp +3 more
openaire +1 more source
Advanced Healthcare Materials, EarlyView.The synthesis process of MM@PCD@QNPs and its potential mechanism for treating PCOS. (A) Assembly steps of MM@PCD@QNPs. (B) Synthesis and decomposition of MM@PCD@QNPs. (C) Potential therapeutic mechanisms of MM@PCD@QNPs for PCOS. PCD, PABP conjugated with DEX polymer; QUR, quercetin; CDI, N, N′‐carbonyldiimidazole; DEX, dextran; PABP, 4‐(hydroxymethyl ...
Wenzhu Li +9 more
wiley +1 more source
Population Medicine, 2022 Introduction This study sought to investigate the trend and factors associated with DHT (Digital Health Tools) utilization among individuals with SPD (serious psychological distress) in the US.
Henry K. Onyeaka +7 more
doaj +1 more source
Advanced Science, EarlyView.GNL3 is a novel AR coregulator with dual coactivator and corepressor functions in prostate cancer (PCa). Our study uncovers a previously unrecognized mechanism by which the AR transcriptional complex integrates oncogenic signaling and immune suppression.
Cuiting Zhang +12 more
wiley +1 more source
Advanced Science, EarlyView.This study reveals a pivotal epigenetic regulatory role for the histone acetyltransferase p300, demonstrating that its acetylation of histone 3 at lysine 18 and 27 (H3K18ac and H3K27ac), alongside the formation of the p300/BRD4/SP1 complex, drives AR activation and ovarian fibrosis in PCOS.
Zhengquan Zhu +11 more
wiley +1 more source
Dihydrotestosterone ameliorates degeneration in muscle, axons and motoneurons and improves motor function in amyotrophic lateral sclerosis model mice. [PDF]
PLoS ONE, 2012 Amyotrophic lateral sclerosis (ALS) is a lethal disease characterized by a progressive loss of motoneurons. The clinical symptoms include skeletal muscle weakness and atrophy, which impairs motor performance and eventually leads to respiratory failure ...
Young-Eun Yoo, Chien-Ping Ko
doaj +1 more source
Molecules, 2022 Autocrine and paracrine factors play key roles in the process of Androgenetic alopecia (AGA), which are secreted by balding dermal papilla cells (DPCs) after dihydrotestosterone (DHT) induction. Camellia seed cake is an oriental oil extraction byproduct,
Ling Ma +4 more
doaj +1 more source