Results 41 to 50 of about 17,491 (180)
Advanced Science, EarlyView.Impaired endometrial receptivity contributes to the poor pregnancy outcomes in women with PCOS. The authors found that decreased endometrial IL‐22 levels and disrupted STAT3‐IGFBP5 signaling pathway contributed to impaired endometrial receptivity. Supplementation with IL‐22 or IGFBP5 exerts a protective effect on implantation failure in PCOS‐like mice,
Baoying Liao +13 more
wiley +1 more source
Decidualized endometrial stromal cells present with altered androgen response in PCOS
Scientific Reports, 2021 Hyperandrogenic women with PCOS show disrupted decidualization (DE) and placentation. Dihydrotestosterone (DHT) is reported to enhance DE in non-PCOS endometrial stromal cells (eSCCtrl); however, this has not been assessed in PCOS cells (eSCPCOS ...
Masuma Khatun +12 more
doaj +1 more source
Fertility & Reproduction, 2022 Background: Polycystic ovary syndrome (PCOS) is a common disorder characterised by endocrine, reproductive and metabolic dysfunction. Hyperandrogenism is a key diagnostic trait and evidence supports a role for androgen receptor (AR) mediated actions in ...
Ting XIONG +9 more
doaj +1 more source
Highly Available DHTs: Keeping Data Consistency After Updates [PDF]
, 2006 The research in the paper is motivated by building a decentralized/P2P XML storage on top of a DHT (Distributed Hash Table). The storage must provide high data availability and support updates. High data availability in a DHT can be guaranteed by data replication.
Knežević, Predrag +2 more
openaire +1 more source
Advanced Science, EarlyView.Disrupted neurovascular coupling contributes to ovarian dysfunction in polycystic ovary syndrome. Using near‑infrared II long‑wavelength imaging, this study visualizes how electroacupuncture dynamically regulates ovarian blood vessels in vivo. Immediate and cumulative stimulation elicit distinct vascular responses via a Netrin‐1 dependent mechanism ...
Yicong Wang +15 more
wiley +1 more source
Advanced Science, EarlyView.Prostate cancer remains a leading cause of male cancer death, yet screening cannot reliably identify aggressive disease, underscoring the need for tissue biomarkers. It is shown that primary tumors increase ER–plasma membrane junction signaling via STIM1/ORP5, whereas metastasis features their loss, Golgi dispersal, and rapid conversion of high‐mannose
Amanda J. Macke +14 more
wiley +1 more source
Androgen interacts with exercise through the mTOR pathway to induce skeletal muscle hypertrophy
Biology of Sport, 2017 This study was designed to investigate the effects of exogenous androgen and resistance exercise on skeletal muscle hypertrophy and the role of the mammalian target of rapamycin (mTOR) signalling during the process. A total of 24 male Sprague-Dawley rats
Fanxing Zeng, Hua Zhao, Jingwen Liao
doaj +1 more source
Physicochemical and Mechanical Characterization of Commercial Collagen‐Based Wound Dressings
Advanced NanoBiomed Research, EarlyView.Commercial collagen‐based wound dressings are systematically compared to reveal how porous architecture governs hydration‐driven swelling and mechanical adaptation. Distinct structure–function relationships are identified, showing that wet‐state elasticity and conformability emerge from material composition and processing rather than manufacturer ...
Davide V. Verdolino +4 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.With the increasing volume of clinical evidence derived from large‐scale Asian real‐world data (RWD) and the growing interest in its use in regulatory decision‐making, it is important to conduct benchmarking exercises that evaluate whether studies using Asian RWD can generate similar conclusions as randomized controlled trials (RCTs).
Hwa Yeon Ko +15 more
wiley +1 more source
Lipids in Health and Disease, 2012 Background Administration of androgens decreases plasma concentrations of high-density lipid cholesterol (HDL-C). However, the mechanisms by which androgens mediate lipid metabolism remain unknown.
Yi-zhou Ye +10 more
doaj +1 more source