Results 81 to 90 of about 62,466 (229)

CDK4/MERCs/PINK1 Axis Drives PFOA/HFPO‐TA‐Induced Cardiac Senescence via Mitophagy Defect and cGAS‐STING Activation: In Vitro Amelioration by Cycloastragenol

Advanced Science, EarlyView.
The present study demonstrated that PFOA and HFPO‐TA exposure suppressed CDK4, disrupted MERCs and impaired PINK1/Parkin‐mediated mitophagy, thereby accelerating cardiac senescence, whereas CAG effectively reversed these pathological changes in vitro. Our findings identify CDK4 as a critical regulator bridging mitophagy defects and cardiac senescence ...
Nuo‐Wa Li, Jun‐Ze Jiang, Ying‐Ying Liu, Tian‐Tian Zhang, Kanwar Kumar Malhi, Xin Yao, Jin‐Long Li   +6 more
wiley   +1 more source

CORONARY RESERVE AND LEFT VENTRICLE DIASTOLIC FUNCTION AS EVALUATED BY TRANSESOPHAGEAL CARDIAC PACING IN PATIENTS FOLLOWING MYOCARDIAL INFARCTION

Российский кардиологический журнал, 2003
Evaluation to determine the relationship between coronary reserve and myocardium diastolic function was performed in 58 patients surviving a Q-wave myocardial infarction an average of 2. 4 months ago.
A. P. Ivanov, I. A. Elhardt, N. S. Sdobnyakova, V. G. Patrikeyev   +3 more
doaj  

SerpinA3 is an Endogenous TGF‐β Receptor Antagonist that Attenuates Cardiac Fibroblast Activation and Fibrotic Remodeling

Advanced Science, EarlyView.
SerpinA3 acts as an endogenous TGF‐β receptor antagonist that binds to the extracellular domain of TGFR‐1, thereby preventing TGFR‐1–TGFR‐2 complex formation. This receptor‐level blockade suppresses TGF‐β/Smad2/3 signaling, attenuates cardiac fibroblast activation, and extracellular matrix deposition, and ultimately alleviates pressure overload–induced
Hui Wang, Jieyu Cui, Chunlu Huang, Wanyi Guo, Tong Liu, Yi Zhu, Shuai Shao, Kangyin Chen, Jinlong He, Qiankun Bao   +9 more
wiley   +1 more source

Anfíbio: coração: diástole atrial

, 2014
Apresenta coração de anuro em vista dorsal, com destaque para o sincronismo entre a sístole ventricular e a diástole atrialComponente Curricular::Educação Superior::Ciências Biológicas::Biologia GeralComponente Curricular::Educação Superior::Ciências ...
Sebben, Antonio
core  

Increased Disarray of Extracellular Matrix Collagen‐I Fiber Network and Compromised Biomechanics in Aortae From Marfan‐Syndrome Mice Assessed Through Combined Opto‐Biomechatronics

Advanced Science, EarlyView.
Combined structure‐function assessment in aortic rings from Marfan mice using MechaMorph Opto‐Biomechatronics technology relates increased elasticity (stiffness) and dynamic viscosity and less ordered extracellular matrix 3D‐structure (collagen) as potential causes for impaired Windkessel function and compromised haemodynamics in Marfan's syndrome ...
Dominik Schneidereit, Anika Nagel, Vanessa I. T. Zwaans, Laureen Schurr, Jonas Ahr, Michael Haug, Anna Piluso, Alexandra Sporkova, Matthias Karck, Andreas H. Wagner, Oliver Friedrich   +10 more
wiley   +1 more source

Motion-compensated spin-echo cardiac diffusion tensor imaging in multiple cardiac phases using an ultrahigh gradient strength scanner

Journal of Cardiovascular Magnetic Resonance
Background: Cardiac diffusion tensor imaging (cDTI) has traditionally relied on inefficient stimulated echo techniques to robustly assess microstructural changes over the cardiac cycle.
Shubhajit Paul, Camila Munoz, Pedro F. Ferreira, C.John Evans, Sonya Foley, Fabrizio Fasano, Derek K. Jones, Dudley J. Pennell, Sonia Nielles-Vallespin, Andrew D. Scott   +9 more
doaj   +1 more source

Entre sístole y diástole [PDF]

, 2019
Dos mujeres de aspecto particular residen en un espacio de trabajo en donde realizan una serie de actividades de creación. Una de ellas tiene poder sobre la otra, quien obedece y ejecuta las acciones que se le ordenan.
Castellar Pacheco, Blanca Stella
core  

Gut Microbiota‐Derived Indole‐3‐Propionic Acid Alleviates Diabetic Osteoporosis Through Nrf2‐Mediated Ferroptosis Suppression

Advanced Science, EarlyView.
Diabetes‐associated dysbiosis is accompanied by reduced Clostridium abundance, impaired microbial tryptophan metabolism, and lower circulating indole‐3‐propionic acid (IPA). Exogenous IPA improves trabecular microarchitecture and bone formation and restores Nrf2‐associated antioxidant signaling in bone marrow mesenchymal stem cells, limiting iron ...
Jinwu Bai, Qinyong You, Gao Si, Daole Hu, Ao Sun, Shilong Su, Ruideng Wang, Jixing Fan, Shan Gao, Tengjiao Zhu, Chun‐Li Song, Fang Zhou, Yang Lv   +12 more
wiley   +1 more source

The effect of cardiac phase on distractor suppression and motor inhibition in a stop-signal task

Scientific Reports
Past work has shown that stimuli timed to the cardiac systole, the time at which heartbeat feedback is transmitted to the brain, can be more effectively selected from conflicting information.
Amanda C. Marshall, Qiaoyue Ren, Lioba Enk, Junhui Liu, Simone Schütz-Bosbach   +4 more
doaj   +1 more source

Anfíbio: coração: diástole ventricular

, 2014
Apresenta coração de anuro em vista ventral no momento da diástole ventricularComponente Curricular::Ensino Médio::BiologiaComponente Curricular::Educação Superior::Ciências Agrárias::Medicina VeterináriaComponente Curricular::Educação Superior::Ciências
Sebben, Antonio
core