Results 51 to 60 of about 21,413 (223)

GSK3α‐mediated regulation of the RNA demethylase fat mass and obesity‐associated protein (FTO) during murine spermatogenesis

The FEBS Journal, EarlyView.
FTO regulates mRNA stability and translational efficiency through its m6A‐demethylation activity. GSK3 functions as an upstream regulator of FTO, leading to its inhibition via phosphorylation. In male germ cells, FTO activity is kept in check by GSK3α.
Neha Choudhari, Budheswar Dehury, Rounak Roy, Radhakrishnan Periyasamy, Indrashis Bhattacharya, Mahesh Sahare, Srinivasan Vijayraghavan, Souvik Dey   +7 more
wiley   +1 more source

Chronic Toxicity of Di(2-ethylhexyl)phthalate in Mice [PDF]

Toxicological Sciences, 2000
B6C3F1 mice were treated with 0, 100, 500, 1500, or 6000 ppm di(2-ethylhexyl)phthalate (DEHP) in the diet for up to 104 weeks. Blood and urine were analyzed at Weeks 26, 52, 78, and 104 from 10 animals per sex per group. Body weights and food consumption were measured weekly for the first 16 weeks, then monthly thereafter. Survival was reduced for mice
R M, David, M R, Moore, D C, Finney, D, Guest   +3 more
openaire   +2 more sources

Evaluating the protective effects of melatonin on di(2-ethylhexyl) phthalate-induced testicular injury in adult mice.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018
OBJECTIVE Di (2-ethylhexyl) phthalate (DEHP) is a common phthalate derivative, interfering with normal function of reproductive system. The present study evaluated effects of melatonin on DEHP-induced testicular injury in mice.
N. Bahrami, M. Goudarzi, A. Hosseinzadeh, S. Sabbagh, R. Reiter, S. Mehrzadi   +5 more
semanticscholar   +1 more source

Red blood cells stored in anticoagulant versus additive solution for large volume transfusions in pediatric patients undergoing cardiopulmonary bypass

Transfusion, EarlyView.
Abstract Background The safety of red blood cells (RBCs) in additive solutions (AS) for large‐volume transfusion (LVT) in pediatrics remains understudied. This study examines the laboratory and clinical impact of CPD‐stored products versus CP2D/AS‐3 products in pediatric patients receiving LVT during cardiac surgery.
Nabiha H. Saifee, Meghan Delaney
wiley   +1 more source

Determination of Phthalate Metabolites in Human Serum and Urine as Biomarkers for Phthalate Exposure Using Column-Switching LC-MS/MS

Safety and Health at Work, 2011
Objectives:Although phthalates like dibutyl phthalate (DBP) and di-2-ethylhexyl phthalate (DEHP) are commonly used as plasticizers and their metabolites are especially suspected of reproductive toxicity, little is known about occupational exposure to ...
Jee Yeon Jeong, Ji Hyun Lee, Eun Young Kim, Pan Gyi Kim, Young Lim Kho   +4 more
doaj   +1 more source

Measurement of Phthalates in Settled Dust in University Dormitories and Its Implications for Exposure Assessment

Atmosphere, 2023
Six phthalates: dimethyl phthalate (DMP), diethyl phthalate (DEP), di(n-butyl) phthalate (DnBP), butyl benzyl phthalate (BBzP), di(2-ethylhexyl) phthalate (DEHP), and di(n-octyl) phthalate (DOP) in settled dust on different indoor surfaces were measured ...
Jiahui Wang, Fangzhou Yuan, Haitian Ye, Zhongming Bu   +3 more
doaj   +1 more source

Evaluation of the in vitro quality of X‐ray irradiated red cell concentrates processed and stored using di(2‐ethylhexyl) terephthalate plasticized blood bag sets

Vox Sanguinis, EarlyView.
Abstract Background and Objectives Polyvinyl chloride (PVC) blood bags plasticized with di(2‐ethylhexyl) phthalate (DEHP) have long been the standard for red blood cell (RBC) storage. Due to safety concerns, alternatives like di(2‐ethylhexyl) terephthalate (DEHT), in combination with next‐generation additive solutions like phosphate‐adenine‐glucose ...
Carly Olafson, Sanaz Hemmatibardehshahi, Geraldine M. Walsh, Anita Howell   +3 more
wiley   +1 more source

Phthalate esters in water and sediment of Asunle stream of Obafemi Awolowo University, Ile-Ife, Nigeria: Distribution and human health risks

Heliyon
This study determined the concentrations and seasonal variations of phthalate esters (PAEs) in water and sediment samples of the receiving stream within the vicinity of the Obafemi Awolowo University, Ile-Ife dumpsite.
J.O. Fagbemi, J.A.O. Oyekunle, A.O. Ogunfowokan, F. Cheng, L. Deobald   +4 more
doaj   +1 more source

Di(2‐Ethylhexyl) Phthalate Exposure and Risk of Diabetic Kidney Disease: Epidemiological Association and Mechanistic Insights

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 6, September 2026.
ABSTRACT Objective This study aims to explore the association between exposure to di‐(2‐ethylhexyl) phthalate (DEHP) and diabetic kidney disease (DKD), and to elucidate its potential molecular mechanisms. The study findings provide scientific evidence for the prevention and control of environmental risk factors related to DKD.
Dapeng Yin, Yan Li, Wei Wu, Xiaojuan Wang, Junhua He, Yikun Zhu, Jin Li   +6 more
wiley   +1 more source

Fetal bisphenol and phthalate exposure and early childhood growth in a New York City birth cohort

Environment International
Background: Exposure to endocrine-disrupting chemicals such as bisphenols and phthalates during pregnancy may disrupt fetal developmental programming and influence early-life growth.
Sophia M. Blaauwendraad, Sarvenaz Shahin, Carol Duh-Leong, Mengling Liu, Kurunthachalam Kannan, Linda G. Kahn, Vincent W.V. Jaddoe, Akhgar Ghassabian, Leonardo Trasande   +8 more
doaj   +1 more source