Results 271 to 280 of about 1,073,655 (357)

Nanomedicines Against Mitochondrial Dysfunction‐Induced Metabolic Diseases

Advanced Science, EarlyView.
Mitochondrial dysfunction is central to metabolic diseases. Nanomedicine offers transformative approaches for restoring function via targeted delivery, responsive release, and multimodal therapy. This review outlines the pathological basis, nanocarrier design, organelle‐specific targeting, recent advances, and future clinical translation challenges ...
Ke Xu, Leyi Wang, Tao Lv, Chen Jin, Qiong Wu, Yongjie Zhou, Gang Xu, Zhenyu Duan, Kui Luo, Jiayin Yang   +9 more
wiley   +1 more source

Identifying Key Questions and Challenges in Microchimerism Biology

Advanced Science, EarlyView.
This study identifies key unanswered questions about microchimerism, the presence of cells from one individual living in another. Experts highlight how these cells may affect health, pregnancy, and disease. This study outlines research priorities and challenges in detecting and studying these rare microchimeric cells, aiming to guide future discoveries
Kristine J. Chua, Rachel C. Quilang, Katja Sallinger, Christina Athena Aktipis, Petra Arck, Diana W. Bianchi, Hyun‐Dong Chang, Henderson J. Cleaves II, Michael Eikmans, Heidi E. S. Fjeldstad, David Haig, Whitney E. Harrington, William Horsnell, Daniel P. Jacobsen, Mads Kamper‐Jørgensen, Sami B. Kanaan, Kiarash Khosrotehrani, Nathalie C. Lambert, Jane Lee Nelson, Maria B. Olsen, Tiffany D. Pan, Jelmer R. Prins, Frank A. Schildberg, Anne Cathrine Staff, Anders Ståhlberg, Ina A. Stelzer, Christopher Urbschat, Sing Sing Way, Melissa A. Wilson, Jody Ye, Thomas Kroneis, Amy M. Boddy   +31 more
wiley   +1 more source

Japan Diabetes Complications Study: Revisiting one of the first large-scale clinical studies in East Asians with diabetes. [PDF]

J Diabetes Investig
Sone H, Horikawa C, Tanaka-Mizuno S, Kawasaki R, Fujihara K, Moriya T, Araki A, Tanaka S, Akanuma Y.   +8 more
europepmc   +1 more source

Medicago Sativa L. Saponin‐Driven Lactobacillus Intestinalis Restores Intestinal Stemness in Naturally Aged Mice via the Bile Acid‐FXR‐Wnt Signaling Axis

Advanced Science, EarlyView.
This study examines the mechanism by which alfalfa saponin (AS) regulates intestinal stemness via modulation of the gut microbiota. The results indicate that AS significantly increases the abundance of Lactobacillus intestinalis, which subsequently activates Wnt signaling via bile acid metabolism and enhances intestinal stemness. These findings provide
Mengqi Liu, Jiamin Sun, Zuyang Jia, Yalei Cui, Xiaoyan Zhu, Zhichang Wang, Hao Sun, Boshuai Liu, Yinghua Shi   +8 more
wiley   +1 more source

Relationships of Multidimensional Factors to Diabetes Complications: A Cross-Sectional, Correlational Study. [PDF]

West J Nurs Res
Heo S, Kang J, Barbé T, Kim J, Bertulfo TF, Troyan P, Streit L, Slocumb RH.   +7 more
europepmc   +1 more source

The Insulin‐Like Growth Factor System and Neurological Complications in Diabetes

, 2003
Anders A. F. Sima, Zhenguo Li, Wei‐xian Zhang   +2 more
openalex   +1 more source

Gold Nanoturf‐Mediated Wireless Photothermal Upregulation of Human Adipose‐Derived Stem Cell Spheroids for Synergistic Skin‐Wound Closure

Advanced Science, EarlyView.
A wireless skin‐wound care platform for photothermal‐stem cell‐light (PTSCL) therapy, introduced here, leverages a fully wireless and battery‐free optoelectronic module, gold nanoturf‐mediated photothermal interface, and human adipose‐derived stem cell (hADSC) spheroids to synergistically enhance wound healing.
Jong Uk Kim, Jiyu Hyun, Gyan Raj Koirala, Jiwon Kim, Sung‐Won Kim, Gwang‐Bum Im, Yeong Hwan Kim, Young Gil Kim, Dong‐Hyun Lee, Hyun Su Park, Young‐Ju Jang, Young Jin Jo, Chanho Jeong, Arpan Koirala, Janghoon Joo, Sang Min Won, Suk Ho Bhang, Tae‐il Kim   +17 more
wiley   +1 more source

Association between hyperglycaemia, diabetes complications and development of fibrotic conditions among people living with type 1 and type 2 diabetes in England: a retrospective cohort study using UK Clinical Resource Datalink Aurum and Hospital Episode Statistics. [PDF]

BMJ Open
Massen GM, Cook S, Moss ST, Chambers R, Jenkins G, Allen RJ, Wain LV, Stewart I, Oliver N, Morganstein DL, Quint JK, DEMISTIFI Consortium.   +11 more
europepmc   +1 more source

The Pivotal Role of GR‐CAR Pathway in Fetal Programming of Hepatic Cytochrome P450 3A Alteration in Adulthood

Advanced Science, EarlyView.
Prenatal dexamethasone exposure (PDE) persistently upregulates hepatic CYP3A1/CYP2B1 in offspring via glucocorticoid receptor (GR) activation. In vivo and in vitro studies show GR promotes P300/CBP binding to the constitutive androstane receptor (CAR) promoter, sustaining histone acetylation (H3K9/K27ac) and enhancing CYP expression. The GR–CAR pathway
Xiaoxiang Sun, Jie Liu, E Xiang, Xia Li, Xuerong Yan, Yuxi Wang, Feng Li, Hao Kou, Hui Wang, Yu Guo   +9 more
wiley   +1 more source

Nonadherence to Diabetes Complications Screening in a Multiethnic Asian Population: Protocol for a Mixed Methods Prospective Study.

JMIR Res Protoc
Aravindhan A, Fenwick E, Wing Dan Chan A, Eyn Kidd Man R, Ee Tang W, Chuan Tan N, Sabanayagam C, Chay J, Pui Ng L, Teen Wong W, Fern Soo W, Wei Lim S, Lamoureux EL.   +12 more
europepmc   +1 more source