Nephrogenic Diabetes Insipidus [PDF]
Pediatric Clinics of North America, 2019 Nephrogenic diabetes insipidus (NDI) results from the inability of the late distal tubules and collecting ducts to respond to vasopressin. The lack of ability to concentrate urine results in polyuria and polydipsia. Primary and acquired forms of NDI exist in children. Congenital NDI is a result of mutation in AVPR2 or AQP2 genes.
Catherine, Kavanagh, Natalie S, Uy
exaly +5 more sources
Characterization of three vasopressin receptor 2 variants: an apparent polymorphism (V266A) and two loss-of-function mutations (R181C and M311V). [PDF]
, 2013 Arginine vasopressin (AVP) is released from the posterior pituitary and controls water homeostasis. AVP binding to vasopressin V2 receptors (V2Rs) located on kidney collecting duct epithelial cells triggers activation of Gs proteins, leading to increased
Armstrong, Stephen P +4 more
core +4 more sources
Central and nephrogenic diabetes insipidus: updates on diagnosis and management [PDF]
Frontiers in EndocrinologyKathryn Flynn +2 more
exaly +2 more sources
Incidence, severity and prognosis associated with hypernatremia in dogs and cats. [PDF]
, 2015 BackgroundHypernatremia has been associated with substantial morbidity and death in human patients. The incidence and importance of hypernatremia in dogs and cats has not been determined.Hypothesis/objectivesTo describe the incidence of and prognosis ...
Epstein, SE, Hopper, K, Ueda, Y
core +2 more sources
Altered agonist sensitivity of a mutant V2 receptor suggests a novel therapeutic strategy for nephrogenic diabetes insipidus. [PDF]
, 2014 Loss of function mutations of the type 2 vasopressin receptor (V2R) in kidney can lead to nephrogenic diabetes insipidus (NDI). We studied a previously described, but uncharacterized mutation of V2R (N321K missense mutation) of an NDI patient.
Balla, András +5 more
core +1 more source
Signaling Modification by GPCR Heteromer and Its Implication on X-Linked Nephrogenic Diabetes Insipidus [PDF]
, 2016 published_or_final_versio
Chow, BKC +3 more
core +1 more source
Aquaporin modulators: a patent review (2010-2015) [PDF]
, 2016 Introduction: Since the discovery of aquaporin-1 (AQP1) as a water channel, more than 2,000 articles, reviews and chapters have been published.
Casini, Angela, Soveral, Graça
core +1 more source
Nephrogenic diabetes insipidus
Current Opinion in Pediatrics, 2017 Purpose of review In nephrogenic diabetes insipidus (NDI), the kidney is unable to concentrate urine despite elevated concentrations of the antidiuretic hormone arginine-vasopressin. In congenital NDI, polyuria and polydipsia are present from birth and should be immediately recognized to avoid severe episodes of
Bockenhauer, D, Bichet, DG
openaire +3 more sources
Nephrogenic syndrome of inappropriate antidiuresis secondary to an activating mutation in the arginine vasopressin receptor AVPR2. [PDF]
, 2016 CONTEXT: Nephrogenic syndrome of inappropriate antidiuresis (NSIAD), resulting from activating mutations in the arginine vasopressin receptor type 2 (AVPR2), is a rare cause of hyponatraemia.
Adrogué +35 more
core +2 more sources
Physiopathological Implications of 7TM Receptors [PDF]
, 2010 Seven-transmembrane (7TM) receptors are one of the most important proteins involved in perception of extracellular stimuli and regulation of variety of intracellular signaling pathways.
Cygankiewicz, Adam
core +2 more sources