Results 91 to 100 of about 7,250 (205)

Contextualizing guidelines for the health system of Cyprus: Experiences and lessons learnt

open access: yesClinical and Public Health Guidelines, Volume 2, Issue 2, April 2025.
Abstract Background Cyprus is undergoing a major health reform with the recent establishment of the General Healthcare System (GHS). The GHS offers equal healthcare access through one primary insurer (Health Insurance Organization [HIO]) and benefits from a wide collaborative network of public and private healthcare providers.
Panayiotis Kouis   +49 more
wiley   +1 more source

Lithium and its relation with the epithelial sodium channel and aquaporin-2 [PDF]

open access: yes, 2012
Desde hace más de cuarenta años que el litio es usado para el tratamiento de la enfermedad bipolar; recientes estudios sugieren también su utilidad en el trastorno cognitivo mínimo tipo amnésico. El litio es filtrado en el glomérulo y un 65-75% del mismo
Galizia, Luciano   +2 more
core  

Evolutionary aspects in evaluating mutations in the melanocortin 4 receptor [PDF]

open access: yes, 2007
More than 70 missense mutations have been identified in the human melanocortin 4 receptor (MC4R), and many of them have been associated with obesity. In a number of cases, the causal link between mutations in MC4R and obesity is controversially discussed.
Annette Grüters   +34 more
core   +1 more source

Kidney function decline improves after lithium discontinuation

open access: yesJournal of Internal Medicine, Volume 297, Issue 3, Page 289-299, March 2025.
Abstract Background Long‐term lithium treatment decreases kidney function. However, it remains unclear whether stopping lithium improves kidney function. Objectives To study kidney function in patients who stopped and subsequently restarted lithium treatment. Methods Mirror‐image design using data from the LiSIE retrospective cohort study.
Filip Fransson   +4 more
wiley   +1 more source

COX-2 disruption leads to increased central vasopressin stores and impaired urine concentrating ability in mice [PDF]

open access: yes, 2011
It was hypothesized that cyclooxygenase-2 (COX-2) activity promotes urine concentrating ability through stimulation of vasopressin (AVP) release after water deprivation (WD).
Bie, Peter   +6 more
core   +1 more source

Primary Amenorrhea in a 15‐Year‐Old Girl Leading to the Diagnosis of Bardet‐Biedl Syndrome: A Case Report

open access: yesClinical Case Reports, Volume 13, Issue 1, January 2025.
ABSTRACT This case report highlights the clinical complexity of Bardet‐Biedl syndrome, a rare autosomal recessive disorder, emphasizing reproductive anomalies to aid in diagnosis and management. It underscores the importance of thorough assessment and advocates for genetic testing to optimize care, despite current financial, and laboratory constraints.
Azka Noor   +3 more
wiley   +1 more source

Claudins in the Renal Collecting Duct [PDF]

open access: yes, 2019
The renal collecting duct fine-tunes urinary composition, and thereby, coordinates key physiological processes, such as volume/blood pressure regulation, electrolyte-free water reabsorption, and acid-base homeostasis.
Leiz, Janna, Schmitt-Ott, Kai M.
core   +1 more source

Diabetes insípida central en un perro [PDF]

open access: yes, 1999
Se describe un caso de diabetes insípida central [DIC] en un perro. Este caso es particularmente interesante pues se observan modificaciones electrolíticas poco habituales.
Cano Rábano, María José   +4 more
core  

Unravelling drug-induced hypertension: Molecular mechanisms of aldosterone-independent mineralocorticoid receptor activation by posaconazole [PDF]

open access: yes, 2018
Drug-induced hypertension offers the opportunity to further understand pathways involved in the regulation of blood pressure. Posaconazole is an antifungal agent known to induce hypertension and hypokalaemia.
Ortiz, Alberto   +1 more
core   +2 more sources

Protein quality control: the who's who, the where's and therapeutic escapes [PDF]

open access: yes, 2018
In cells the quality of newly synthesized proteins is monitored in regard to proper folding and correct assembly in the early secretory pathway, the cytosol and the nucleoplasm.
Fan, Jingyu   +10 more
core  

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