Contextualizing guidelines for the health system of Cyprus: Experiences and lessons learnt
Abstract Background Cyprus is undergoing a major health reform with the recent establishment of the General Healthcare System (GHS). The GHS offers equal healthcare access through one primary insurer (Health Insurance Organization [HIO]) and benefits from a wide collaborative network of public and private healthcare providers.
Panayiotis Kouis +49 more
wiley +1 more source
Lithium and its relation with the epithelial sodium channel and aquaporin-2 [PDF]
Desde hace más de cuarenta años que el litio es usado para el tratamiento de la enfermedad bipolar; recientes estudios sugieren también su utilidad en el trastorno cognitivo mínimo tipo amnésico. El litio es filtrado en el glomérulo y un 65-75% del mismo
Galizia, Luciano +2 more
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Evolutionary aspects in evaluating mutations in the melanocortin 4 receptor [PDF]
More than 70 missense mutations have been identified in the human melanocortin 4 receptor (MC4R), and many of them have been associated with obesity. In a number of cases, the causal link between mutations in MC4R and obesity is controversially discussed.
Annette Grüters +34 more
core +1 more source
Kidney function decline improves after lithium discontinuation
Abstract Background Long‐term lithium treatment decreases kidney function. However, it remains unclear whether stopping lithium improves kidney function. Objectives To study kidney function in patients who stopped and subsequently restarted lithium treatment. Methods Mirror‐image design using data from the LiSIE retrospective cohort study.
Filip Fransson +4 more
wiley +1 more source
COX-2 disruption leads to increased central vasopressin stores and impaired urine concentrating ability in mice [PDF]
It was hypothesized that cyclooxygenase-2 (COX-2) activity promotes urine concentrating ability through stimulation of vasopressin (AVP) release after water deprivation (WD).
Bie, Peter +6 more
core +1 more source
ABSTRACT This case report highlights the clinical complexity of Bardet‐Biedl syndrome, a rare autosomal recessive disorder, emphasizing reproductive anomalies to aid in diagnosis and management. It underscores the importance of thorough assessment and advocates for genetic testing to optimize care, despite current financial, and laboratory constraints.
Azka Noor +3 more
wiley +1 more source
Claudins in the Renal Collecting Duct [PDF]
The renal collecting duct fine-tunes urinary composition, and thereby, coordinates key physiological processes, such as volume/blood pressure regulation, electrolyte-free water reabsorption, and acid-base homeostasis.
Leiz, Janna, Schmitt-Ott, Kai M.
core +1 more source
Diabetes insípida central en un perro [PDF]
Se describe un caso de diabetes insípida central [DIC] en un perro. Este caso es particularmente interesante pues se observan modificaciones electrolíticas poco habituales.
Cano Rábano, María José +4 more
core
Unravelling drug-induced hypertension: Molecular mechanisms of aldosterone-independent mineralocorticoid receptor activation by posaconazole [PDF]
Drug-induced hypertension offers the opportunity to further understand pathways involved in the regulation of blood pressure. Posaconazole is an antifungal agent known to induce hypertension and hypokalaemia.
Ortiz, Alberto +1 more
core +2 more sources
Protein quality control: the who's who, the where's and therapeutic escapes [PDF]
In cells the quality of newly synthesized proteins is monitored in regard to proper folding and correct assembly in the early secretory pathway, the cytosol and the nucleoplasm.
Fan, Jingyu +10 more
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