Results 31 to 40 of about 23,544 (244)
An AMPK activator as a therapeutic option for congenital nephrogenic diabetes insipidus
JCI Insight, 2021 Nephrogenic diabetes insipidus (NDI) patients produce large amounts of dilute urine. NDI can be congenital, resulting from mutations in the type-2 vasopressin receptor (V2R), or acquired, resulting from medications such as lithium. There are no effective
J. Klein +6 more
semanticscholar +1 more source
Molecular Characterization of an Aquaporin−2 Mutation Causing Nephrogenic Diabetes Insipidus
Frontiers in Endocrinology, 2021 The aquaporin 2 (AQP2) plays a critical role in water reabsorption to maintain water homeostasis. AQP2 mutation leads to nephrogenic diabetes insipidus (NDI), characterized by polyuria, polydipsia, and hypernatremia.
Qian Li +10 more
semanticscholar +1 more source
Incidence, severity and prognosis associated with hypernatremia in dogs and cats. [PDF]
, 2015 BackgroundHypernatremia has been associated with substantial morbidity and death in human patients. The incidence and importance of hypernatremia in dogs and cats has not been determined.Hypothesis/objectivesTo describe the incidence of and prognosis ...
Epstein, SE, Hopper, K, Ueda, Y
core +2 more sources
Clinical Case Reports, 2021 Nephrogenic diabetes insipidus (NDI) is rarely considered against more common differentials such as diabetes mellitus in patients presenting with polydipsia and polyuria.
Esmail Sangey +2 more
doaj +1 more source
Signaling Modification by GPCR Heteromer and Its Implication on X-Linked Nephrogenic Diabetes Insipidus [PDF]
, 2016 published_or_final_versio
Chow, BKC +3 more
core +1 more source
A case of primary aldosteronism combined with acquired nephrogenic diabetes insipidus
Kidney Research and Clinical Practice, 2014 Aldosterone-producing adrenal adenoma can induce various clinical manifestations as a result of chronic exposure to aldosterone. We report a rare case of a 37-year-old man who complained of general weakness and polyuria. He was diagnosed with aldosterone-
Kitae Kim +4 more
doaj +1 more source
Clinical Case Reports, 2021 Patients with nephrogenic diabetes insipidus should establish a support network system by contacting the government to ensure that water can be preferentially obtained in the event of a disaster and create and carry a medical alert card.
Hiroshi Tamura +5 more
doaj +1 more source
Altered agonist sensitivity of a mutant V2 receptor suggests a novel therapeutic strategy for nephrogenic diabetes insipidus. [PDF]
, 2014 Loss of function mutations of the type 2 vasopressin receptor (V2R) in kidney can lead to nephrogenic diabetes insipidus (NDI). We studied a previously described, but uncharacterized mutation of V2R (N321K missense mutation) of an NDI patient.
Balla, András +5 more
core +1 more source
Receptores acoplados à proteína G: implicações para a fisiologia e doenças endócrinas [PDF]
, 2001 The majority of polypeptide hormones and even extracellular calcium signal their target cells through G protein-coupled receptors (GPCRs). Recently, many mutations have been both identified and associated with several endocrine disorders, such as ...
Hauache, Omar M.
core +3 more sources
Frontiers in Pediatrics, 2020 Background and Objectives: Congenital or primary nephrogenic diabetes insipidus (NDI) is a rare genetic disorder that severely impairs renal concentrating ability, resulting in massive polyuria.
Cynthia D'Alessandri-Silva +18 more
semanticscholar +1 more source