Results 161 to 170 of about 813,681 (302)

AI‐Driven De Novo Design of Ultra Long‐Acting GLP‐1 Receptor Agonists

Advanced Science, EarlyView.
De novo GLP‐1RAs can be computationally designed to exhibit extended half‐life and superior efficacy compared to Semaglutide. Abstract Peptide drugs have revolutionized modern therapeutics, offering novel treatment avenues for various diseases. Nevertheless, low design efficacy, time consumption, and high cost still hinder peptide drug design and ...
Ting Wei, Jiating Ma, Xiaochen Cui, Jiahui Lin, Zhuoqi Zheng, Liu Cheng, Taiying Cui, Xiaoqian Lin, Junjie Zhu, Xuyang Ran, Xiaokun Hong, Luke Johnston, Zhangsheng Yu, Haifeng Chen   +13 more
wiley   +1 more source

Polyethylene glycol loxenatide modulates lipid metabolism and insulin resistance through lncRNA steroid receptor RNA activator/cellular nucleic acid binding protein/Rho‐associated coiled‐coil kinase 2 axis in type 2 diabetes mellitus

Journal of Diabetes Investigation
Background Polyethylene glycol loxenatide (PEG‐Loxe) is applied in treating type 2 diabetes mellitus. Nevertheless, the effect and mechanism of PEG‐Loxe on lipid metabolism disorder and insulin resistance in type 2 diabetes mellitus are not fully ...
Zhuangsen Chen, Zhongyu Zhou, Lin Wang, Yanrong Zhang, Caiyan Huang, Cong Wang, Ying Huang, Shanshan Wang, Dewen Yan, Kun Feng   +9 more
doaj   +1 more source

Sweat Wearable Sensor Based on Confined Pt Nanoparticles in 2D Conductive Metal–Organic Frameworks for Continuous Glucose Monitoring

Advanced Science, EarlyView.
An integrated wearable system is developed for nonenzymatic sweat glucose monitoring at the point of care. The system couples a microfluidic patch based on Pt nanoparticles confined in phthalocyanine‐based conductive MOFs with a flexible wireless circuit.
Wei Huang, Yong Yang, Yun Xu, Fei Xiao, Lin Wang   +4 more
wiley   +1 more source

Outcome of human islet isolation and allotransplantation in 20 consecutive cases. [PDF]

, 1992
This report provides our initial experience on islet isolation and intrahepatic allotransplantation in 20 patients. In Group 1, 10 patients underwent combined liver-islet allotransplantation following upper-abdominal exenteration for cancer.
Alejandro, R, Carroll, P, Demetris, AJ, Fung, JJ, Mintz, DH, Ricordi, C, Rilo, HLR, Shapiro, R, Starzl, TE, Tzakis, A, Zeng, Y   +10 more
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ALKBH5‐Mediated M6A Demethylation of G3BP1 Attenuates Ferroptosis Via Cytoplasmic Retention of YBX1/p53 in Diabetic Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
ALKBH5 promoted G3BP1 expression via m⁶A methylation at sites 142/173. G3BP1 interacts with YBX1 and p53, reducing their nuclear translocation and decreasing p53‐mediated SLC7A11 repression. This inhibites cardiomyocyte ferroptosis and mitigates myocardial damage during diabetic ischemia‐reperfusion injury.
Wenyuan Li, Wei Li, Yan Leng, Heng Xu, Zhongyuan Xia, Yao Wang   +5 more
wiley   +1 more source

Comparison between olanexidine gluconate and conventional antiseptics for surgical site infection in gastroenterological surgery: A meta‐analysis

Annals of Gastroenterological Surgery, EarlyView.
This meta‐analysis compared olanexidine gluconate (OLG) with conventional antiseptics on surgical site infections (SSIs) in gastroenterological surgery. OLG significantly reduced overall SSIs without statistical heterogeneity. Abstract Aim To compare the preventative effect of the new antiseptic olanexidine gluconate (OLG) with conventional antiseptics
Akihisa Matsuda, Takeshi Yamada, Kay Uehara, Aya Yamagishi, Hiroshi Yoshida   +4 more
wiley   +1 more source

International Comparison of Geriatric‐Associated Variables in Major Gastroenterological Surgery Between National Clinical Database and American College of Surgeons National Surgical Quality Improvement Program

Annals of Gastroenterological Surgery, EarlyView.
Geriatric surgical risk factors and outcomes were compared between the US and Japanese databases. Geriatric‐associated preoperative variables and outcomes similarly increased with age. Mobility and functional domains differed between the two databases. ABSTRACT Backgrounds Incidence of malignant disease in older patients has been increasing.
Yasuhide Kofunato, Xane Peters, Arata Takahashi, Mark E. Cohen, Hiraku Kumamaru, Mitsukazu Gotoh, Yoshihiro Kakeji, Yasuyuki Seto, Yuko Kitagawa, Ken Shirabe, Hideki Ueno, Hiroaki Miyata, Clifford Y. Ko, Shigeru Marubashi   +13 more
wiley   +1 more source

Report by the Comissió d’Avaluació Econòmica i Impacte Pressupostari, CAEIP (Economic Evaluation and Budget Impact Commission), of Catsalut, about the new medicines for the control of the glucose in type 2 diabetes mellitus commercialized in Catalonia [PDF]

, 2010
Avaluació econòmica de medicaments; Diabetis mellitus tipus 2; Catalunya; Economic evaluation of drugs; Type 2 diabetes mellitus; Catalonia; Evaluación económica de medicamentos; Diabetes mellitus tipo 2; CataluñaEs presenta el Dictamen de la Comissió d ...

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Effect of Intraoperative Posture on Accurate Diagnostic Rate of Intraoperative Nerve Monitoring During Esophagectomy

Annals of Gastroenterological Surgery, EarlyView.
Adequate contact between the intubation tube and the vocal cord muscles is crucial for effective intraoperative nerve monitoring use during esophagectomy. Additionally, intraoperative posture significantly affects diagnostic outcomes and should be carefully considered.
Masami Yuda, Keita Takahashi, Yoshitaka Ishikawa, Takanori Kurogochi, Akira Matsumoto, Naoko Fukushima, Takahiro Masuda, Naoto Takahashi, Fumiaki Yano, Ken Eto   +9 more
wiley   +1 more source

Obstructive sleep apnea risk and associated factors among patients with type 2 diabetes mellitus in Africa: systematic review and meta-analysis

Sleep Science and Practice
Background Although obstructive sleep apnea affects people all across the world, there is limited information about the conditions in developing countries, notably in Africa.
Worku Chekol Tassew, Samson Sisay Woldie, Yeshiwas Ayale Ferede, Agerie Mengistie Zeleke   +3 more
doaj   +1 more source