Results 291 to 300 of about 1,315,356 (337)

Purple and red rice (Oryza sativa L.) bran polyphenols show antiobesity and antidiabetic activities

Cereal Chemistry, EarlyView.
Abstract Background and Objectives Rice bran is a source of bioactive polyphenols. This study aimed to characterize the antidiabetic potential of different rice brans (one brown, two red, and two purple) by examining their ability to inhibit α‐amylase, α‐glucosidase, and pancreatic lipase, and to stimulate glucose uptake in adipocytes.
Stephen M. Boue, William Broussard, Abigail Michelz   +2 more
wiley   +1 more source

Hyaluronic Acid Treatment of Post-Extraction Tooth Socket Healing in Subjects with Diabetes Mellitus Type 2: A Randomized Split-Mouth Controlled Study. [PDF]

J Clin Med
Ruggiero T, Carossa M, Camisassa D, Bezzi M, Rivetti G, Nobile V, Pol R.   +6 more
europepmc   +1 more source

Contemporary Perspectives on Chronic Renal Disorders

Chronic Diseases and Translational Medicine, EarlyView.
ABSTRACT The prevalence of renal diseases and its associated burden on healthcare have tremendously risen in the past few years. From simple markers assessing kidney function, current renal research delves into understanding the diseases at the cellular and molecular levels and not just at treating, but at improving quality of life, arresting ...
Deenadhayalan Ashok, Poornima Ajay Manjrekar, Bhushan C. Shetty, Sujina S. S, Rukmini Mysore Srikantiah, Sowndarya Kollampare   +5 more
wiley   +1 more source

Behavioral health training for integrated behavioral health: A Delphi study

Counselor Education and Supervision, EarlyView.
Abstract Using a classical Delphi design, the authors used an interdisciplinary panel of behavioral health experts in integrated behavioral health (IBH) to identify foundational skills and knowledge counselor educators need to teach clinical mental health counselors for IBH practice. Eighty‐eight statements were identified.
Nicholas Schmoyer, Lisa Corbin, Jessica Huffman, Gülşah Kemer   +3 more
wiley   +1 more source

Total Synthesis of (–)‐Vescalagin, the Iconic Member of the C‐Glucosidic Ellagitannin Family

Chemistry – A European Journal, Accepted Article.
The first total synthesis of the 2,3,5‐O‐(S,R)‐NonaHydroxyTriPhenoylated (NHTP) and 4,6‐O‐(S)‐HexaHydroxy‐DiPhenoylated (HHDP) C‐glucosidic ellagitannin (−)‐vescalagin was accomplished through a bioinspired route involving intramolecular atroposelective cupric‐diamine complex‐mediated phenolic couplings of gallates to forge its HHDP and NHTP units, and
Romain Larrieu, Anaëlle Cornu, Laurent Pouységu, Denis Deffieux, Stéphane Quideau   +4 more
wiley   +1 more source

Type-2 Diabetes Mellitus: risk factors in a school in the health field

, 2000
Maria Carolina Alves Ortiz, María Lúcia Zanetti   +1 more
openalex  

A Phase 1C, Open Label, Single Ascending Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of DM199 Administered Intravenously with a Polyvinyl Chloride Bag in Adult Healthy Subjects and Adults Recently Taking Angiotensin‐Converting Enzyme Inhibitors

Clinical Pharmacology in Drug Development, EarlyView.
Abstract This small phase 1C, open‐label, single ascending dose study evaluated the safety, tolerability, and pharmacokinetics (PKs) of DM199, a recombinant form of human tissue kallikrein‐1 (KLK1). A small sample size of both healthy subjects and hypertensive adults recently taking angiotensin‐converting enzyme inhibitors was studied. KLK1 has a known
Michael Giuffre, Annette D. Lista, Nick Paulson, Lorianne Masuoka   +3 more
wiley   +1 more source

Impact of Model‐Informed Drug Development on Drug Development Cycle Times and Clinical Trial Cost

Clinical Pharmacology &Therapeutics, EarlyView.
Model‐informed drug development (MIDD) integrates data to quantify benefit/risk informing objective drug discovery and development decisions. An additional critical benefit of MIDD is postulated to be improvement in trial and program efficiencies. While the application of MIDD has grown, there have been no clear examples across programs to demonstrate ...
Vaishali Sahasrabudhe, Timothy Nicholas, Gianluca Nucci, Cynthia J Musante, Brian Corrigan   +4 more
wiley   +1 more source

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Type 2 diabetes mellitus

Nature Reviews Disease Primers, 2015
Type 2 diabetes mellitus (T2DM) is an expanding global health problem, closely linked to the epidemic of obesity. Individuals with T2DM are at high risk for both microvascular complications (including retinopathy, nephropathy and neuropathy) and macrovascular complications (such as cardiovascular comorbidities), owing to hyperglycaemia and individual ...
DeFronzo, Ralph A, Ferrannini, Ele, Groop, Leif, Henry, Robert R, Herman, William H, Holst, Jens Juul, Hu, Frank B, Kahn, C Ronald, Raz, Itamar, Shulmann, Gerald I., Simonson, Donald C, Testa, Marcia A, Weiss, Ram   +12 more
openaire   +6 more sources