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Genes and type 2 diabetes mellitus
Current Diabetes Reports, 2008In 2007, five whole genome-wide association studies were published on the genetics of type 2 diabetes mellitus (T2DM), followed by the discovery of 11 genes consistently associated with T2DM. This breakthrough provided the first glimpses of a complete picture of the disease's genetic complexity.
Leif Groop, Valeriya Lyssenko
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Acatalasemia and type 2 diabetes mellitus
Orvosi Hetilap, 2015The catalase enzyme decomposes the toxic concentrations of hydrogen peroxide into oxygen and water. Hydrogen peroxide is a highly reactive small molecule and its excessive concentration may cause significant damages to proteins, deoxyribonucleic acid, ribonucleic acid and lipids. Acatalasemia refers to inherited deficiency of the catalase enzyme.
László Góth +2 more
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Type 2 Diabetes Mellitus in Children
Endocrine Practice, 1998To provide an overview of type 2 diabetes in children and discuss short-term and long-term management strategies.We review the distinction among various types of diabetes mellitus as they apply to children. In addition, we discuss determining the precise diagnosis between the two major variants--type 1 and type 2 diabetes--and clinical management of ...
John H. Pohl +2 more
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1999
Type 2 diabetes mellitus is a disease characterized by both abnormalities in insulin secretion and target-tissue resistance to the actions of insulin. Therefore, it is not surprising that replacement therapy with insulin alone is not sufficient to control blood glucose and many of the other metabolic abnormalities in patients with type 2 diabetes ...
Rubin Bressler, David Johnson
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Type 2 diabetes mellitus is a disease characterized by both abnormalities in insulin secretion and target-tissue resistance to the actions of insulin. Therefore, it is not surprising that replacement therapy with insulin alone is not sufficient to control blood glucose and many of the other metabolic abnormalities in patients with type 2 diabetes ...
Rubin Bressler, David Johnson
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Lixisenatide for type 2 diabetes mellitus
Expert Opinion on Investigational Drugs, 2011Type 2 diabetes mellitus (T2DM) is an increasing health problem worldwide. Glucagon-like peptide-1 (GLP-1) receptor agonists are an expanding drug class that target several of the pathophysiological traits of T2DM. Lixisenatide is a GLP-1 receptor agonist in development for once-daily treatment of T2DM.Pharmacological, preclinical and clinical evidence
Christensen, Mikkel +3 more
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The complex link between NAFLD and type 2 diabetes mellitus — mechanisms and treatments
Nature reviews: Gastroenterology & hepatology, 2021G. Targher, K. Corey, C. Byrne, M. Roden
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Hyperuricaemia and type 2 diabetes mellitus
Clinical and Experimental Pharmacology and Physiology, 2018SummaryChoi et al reported the effect of hyperuricaemia on the new‐onset type 2 diabetes mellitus (T2DM). I present three queries. (i) Insulin is considered to stimulate uric acid reabsorption via specific transporter and the effect of hyperuricaemia on the new‐onset T2DM should be evaluated by considering insulin resistance. (ii) There is a limitation
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Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure
Nature Reviews Endocrinology, 2020D. Eizirik, L. Pasquali, M. Cnop
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