Results 21 to 30 of about 1,032,909 (125)

Adiposity-Related Heterogeneity in Patterns of Type 2 Diabetes Susceptibility Observed in Genome-Wide Association Data [PDF]

, 2009
OBJECTIVE-This study examined how differences in the BMI distribution of type 2 diabetic case subjects affected genome-wide patterns of type 2 diabetes, association mid considered the implications for the etiological heterogeneity of type 2 diabetes ...
Timpson, NJ, David P. Strachan, Weedon, Michael N., Weedon, MN, Nicholas J. Timpson, Rayner, NW, Morris, Andrew D., Zeggini, Eleftheria, Mark Walker, Alex S.F. Doney, Doney, ASF, Palmer, Colin N A, Timothy M. Frayling, Strachan, David P., Hitman, Graham A., Lindgren, Cecilia M., Hattersley, Andrew T., Hitman, GA, Lindgren, CM, Randall, Joshua, Doney, Alex S. F.; id_orcid, Graham A. Hitman, Andrew T. Hattersley, Walker, Mark, Palmer, CN, Hattersley, AT, Rayner, N. William, McCarthy, MI, Timpson, Nicholas J., Michael N. Weedon, Willem H. Ouwehand, Palmer, CNA, Walker, M, Andrew D. Morris, Doney, Alex S F, N. William Rayner, Lindgren, Cecilia, Randall, J, Mark I. McCarthy, Frayling, Timothy M., Strachan, DP, Morris, AD, Cecilia M. Lindgren, Doney, AS, Joshua Randall, McCarthy, Mark I., Zeggini, E, Eleftheria Zeggini, Ouwehand, WH, Pamler, CAN, Ouwehand, Willem H., Colin N.A. Palmer, Frayling, TM, Palmer, Colin N. A.; id_orcid   +53 more
core   +1 more source

Increased glycation and oxidative damage to apolipoprotein B100 of LDL cholesterol in patients with type 2 diabetes and effect of metformin [PDF]

, 2010
OBJECTIVE The aim of this study was to investigate whether apolipoprotein B100 of LDL suffers increased damage by glycation, oxidation, and nitration in patients with type 2 diabetes, including patients receiving metformin therapy.
Rabbani, Naila, D. Zehnder, A. Ceriello, P. J. Thornalley, N. Rabbani, Zehnder, Daniel, Chittari, Madhu Varma, C. W. Bodmer, Bodmer, Charles W., Ceriello, Antonio, M. V. Chittari, Thornalley, Paul J.   +11 more
core   +1 more source

Alanine Aminotransferase, gamma-Glutamyltransferase, and Incident Diabetes [PDF]

, 2009
OBJECTIVE - To estimate and compare associations of alanine aminotransferase (ALT) and gamma-glutamyltransferase (GGT) with incident diabetes. RESEARCH DESIGN AND METHODS - ALT and GGT were studied as determinants of diabetes in the British Women's ...
Ebrahim, Shah B J, Harris, R, Harris, Ross, Lawlor, D, Sattar, N, Sattar, Naveed, Ebrahim, S, Lawlor, Debbie A, Lawlor, DA, Fraser, Abigail, Davey Smith, George, Harris, RJ, Fraser, A, Davey Smith, G, Ebrahim, Shah, Sattar, NA   +15 more
core   +1 more source

Inside the ‘Black Box’ of Pharmaceuticalisation: NICE, the Permissive Principle and the Case of Anticoagulants

Sociology of Health &Illness, Volume 48, Issue 8, November 2026.
ABSTRACT Sociological interest in pharmaceuticalisation continues to grow, especially regarding the expansion of pharmaceutical use in society. This article presents the first major empirical study focusing on the directionality of pharmaceuticalisation by taking cost‐effectiveness assessment and regulation of anticoagulants in England by the National ...
John Abraham, Gowree Balendran
wiley   +1 more source

No Evidence of Moderated Impulsivity Following Administration of the IMPase Inhibitor Ebselen in Healthy Adults

Human Psychopharmacology: Clinical and Experimental, Volume 41, Issue 3, May 2026.
ABSTRACT Objective Impulsivity is a transdiagnostic risk factor for numerous health morbidities and is strongly associated with early relapse and poor treatment outcomes in addictions and mood‐disorders. Lithium carbonate can be helpful in moderating the impulsive behaviors associated with mania, possibly mediated by reduced myo‐inositol activity ...
Matthew P. G. John, Luke Earnshaw, Nikhil Gauri Shankar, Jawad Sultan Raja, Timothy J. Davies, Phillip J. Cowen, Trevor Sharp, Alberto Salmoiraghi, Robert D. Rogers   +8 more
wiley   +1 more source

The Neuroplastic Narrative and Neuro‐Ecological Diversity: Non‐Pathologizing Biological Foundations for Trauma‐Informed Medical and Mental Health Nursing

International Journal of Mental Health Nursing, Volume 35, Issue 2, April 2026.
ABSTRACT Following the Adverse Childhood Experiences study (1998), a wealth of similar studies has strongly associated experiences of trauma and adversity in childhood with increased risk of poor physical and mental health and undesirable social outcomes in adulthood.
Haley Peckham, Bridget Hamilton
wiley   +1 more source

Clinical Profile and Admission Outcomes of Patients With Acute Pulmonary Embolism at a Resource‐Constrained Hospital in Ghana: A Retrospective Pilot Study

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background and Aims Pulmonary embolism is a cardiovascular disease associated with significant morbidity and mortality. There is a paucity of literature regarding this condition from the Ghanaian perspective. This study aimed at evaluating the clinical profile and admission outcomes of patients with acute pulmonary embolism at the Methodist ...
Prosper Adjei, Samuel Kyeremeh Adjei, Kingsley Owusu Manu   +2 more
wiley   +1 more source

The critical role of methylglyoxal and glyoxalase 1 in diabetic nephropathy [PDF]

, 2014
The discovery of increased formation of methylglyoxal (MG) by cell metabolism in high glucose concentration in vitro suggested possible relevance to diabetes and diabetes complications (1,2).
Rabbani, Naila, Thornalley, Paul J.
core   +1 more source

Homozygous hypomorphic HNF1A alleles are a novel cause of young-onset diabetes and result in sulphonylurea sensitive diabetes [PDF]

, 2020
OBJECTIVE Heterozygous loss-of-function mutations in HNF1A cause maturity-onset diabetes of the young (MODY). Affected individuals can be treated with low-dose sulphonylureas.
Misra, S, Hassanali, N, Juszczak, A, Colclough, Kevin, Oliver, NS, Bennett, AJ, Colclough, K, Valabhji, J, Caswell, R, hassanali, neelam, Misra, Shivani, Valabhji, Jonathan, Bennet, Amanda, Gloyn, Anna, Oliver, Nick, Juszczak, Agata, Ellard, S, Ellard, Sian, Caswell, Richard   +18 more
core   +1 more source

Therapeutic Potential of Hesperidin in Male Infertility: A Comprehensive Review of Mechanistic Insights, Preclinical In Vivo and In Silico Evidence and Future Perspectives

Andrologia, Volume 2026, Issue 1, 2026.
The prevalence of male infertility is increasing at an alarming rate worldwide, impacting millions of people medically, mentally and socially. Hesperidin, a flavanone glycoside abundant in citrus, is described as a novel therapeutic agent for the amelioration of several illnesses.
Rotdelmwa Maimako Asaleye, Adewale Odunayo Oladipo, Monde A. Nyila, Sogolo Lucky Lebelo, Mariana Neves   +4 more
wiley   +1 more source