Results 51 to 60 of about 937,987 (286)

Sestrin2 in diabetes and diabetic complications

Frontiers in Endocrinology, 2023
Diabetes is a global health problem which is accompanied with multi-systemic complications. It is of great significance to elucidate the pathogenesis and to identify novel therapies of diabetes and diabetic complications. Sestrin2, a stress-inducible protein, is primarily involved in cellular responses to various stresses.
Xiaodan Zhang, Zirui Luo, Jiahong Li, Yaxuan Lin, Yu Li, Wangen Li   +5 more
openaire   +3 more sources

Association Between Individualized Education for Kidney Replacement Therapy Modality Selection and Peritoneal Dialysis Initiation: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Peritoneal dialysis (PD) is an established home‐based kidney replacement therapy (KRT), but its uptake remains low in Japan. We evaluated whether individualized education in a dedicated outpatient clinic was associated with the initiation of PD.
Yasuko Ito, Ryuichi Yoshimura, Takaki Yamauchi, Yuta Funakoshi, Hirotaka Sonoda, Seiji Kobayashi, Hiroyuki Terawaki, Takafumi Ito   +7 more
wiley   +1 more source

Stakeholder perceptions on scaling-up community-led interventions for prevention and control of non-communicable diseases in Bangladesh: a qualitative study

BMC Public Health, 2023
Background Engaging communities is an important component of multisectoral action to address the growing burden of non-communicable diseases (NCDs) in low- and middle-income countries.
Kohenour Akter, Abdul Kuddus, Tasnova Jeny, Tasmin Nahar, Sanjit Shaha, Naveed Ahmed, Carina King, Malini Pires, Hassan Haghparast-Bidgoli, Kishwar Azad, Edward Fottrell, Joanna Morrison   +11 more
doaj   +1 more source

Effect of DFPP on Ferroptosis in Peripheral Blood CD14+ Monocytes of Hyperlipidemic Patients Involving the ACSL4/LPCAT3/ALOX5 Pathway

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Hyperlipidemia is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). Although statins are the cornerstone of lipid‐lowering therapy, their use may be limited in some patients by adverse effects. This study evaluated the possible impact of non‐drug treatment using double‐filtration plasmapheresis (DFPP) on CD14+
Yun Cheng, Lan Li, Qingmei Yang, Meipeng Wu   +3 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Successful nonsurgical therapy of a diabetic foot osteomyelitis in a patient with peripheral artery disease with almost complete radiological restoration

BMC Research Notes, 2018
Background Diabetic foot ulcer (DFU) is a common complication in patients with diabetes mellitus (DM) and can consequently lead to soft tissue infection and osteomyelitis.
C. V. Loupa, E. Meimeti, E. Voyatzoglou, A. Donou, E. Koutsantoniou, S. Lafoyanni   +5 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Immunological and genetic factors associated with type 1 diabetic nephropathy [PDF]

, 2000
Väitöskirjaei tietoa saavutettavuudesta unknown ...
Korpinen, Eija
core  

Prevalence and Severity of Coronary Artery Calcification Assessed by Low‐Dose Computed Tomography in Individuals With Type 2 Diabetes With and Without Diabetic Foot: A Cross‐Sectional Study

Journal of Diabetes
Background To investigate whether diabetic foot (DF) is associated with a higher prevalence and severity of coronary artery calcification (CAC) in patients with type 2 diabetes (T2DM) using low‐dose computed tomography (LDCT).
Feiyan Shi, Yun Gao, Mingxin Bai, Ruixue Feng, Chunjie Ma, Dawei Chen, Chun Wang, Lihong Chen, Sen He, Donge Yan, Chunchao Xia, Xingwu Ran   +11 more
doaj   +1 more source

Physiological and Pharmacological Roles of FGF21 in Cardiovascular Diseases

Journal of Diabetes Research, 2016
Cardiovascular disease (CVD) is one of the most severe diseases in clinics. Fibroblast growth factor 21 (FGF21) is regarded as an important metabolic regulator playing a therapeutic role in diabetes and its complications.
Peng Cheng, Fangfang Zhang, Lechu Yu, Xiufei Lin, Luqing He, Xiaokun Li, Xuemian Lu, Xiaoqing Yan, Yi Tan, Chi Zhang   +9 more
doaj   +1 more source