Results 1 to 10 of about 584,253 (240)

Diabetic angiopathy and angiogenic defects. [PDF]

Fibrogenesis Tissue Repair, 2012
Abstract Diabetes is one of the most serious health problems in the world. A major complication of diabetes is blood vessel disease, termed angiopathy, which is characterized by abnormal angiogenesis. In this review, we focus on angiogenesis abnormalities in diabetic complications and discuss its benefits and drawbacks as a therapeutic target
Xu L, Kanasaki K, Kitada M, Koya D.
europepmc   +8 more sources

Protective effect of the curcumin-baicalein combination against macrovascular changes in diabetic angiopathy. [PDF]

Front Endocrinol (Lausanne), 2022
Endothelial dysfunction is an early pathological event in diabetic angiopathy which is the most common complication of diabetes. This study aims to investigate individual and combined actions of Curcumin (Cur) and Baicalein (Bai) in protecting vascular ...
Wang C, Sun Y, Liu W, Liu Y, Afzal S, Grover J, Chang D, Münch G, Li CG, Lin S, Chen J, Zhang Y, Cheng Z, Lin Y, Zheng Y, Huang M, Zhou X.   +16 more
europepmc   +3 more sources

Gene therapy targeting inflammatory pericytes corrects angiopathy during diabetic wound healing [PDF]

Frontiers in Immunology, 2022
Wound healing is impaired in the diabetic status, largely attributable to diabetes-associated angiopathy. Pericytes play critical roles in the stabilization of the formed vessels.
Wenxv Jin, Xiong Chen, Lingguo Kong, Chongqing Huang   +3 more
doaj   +3 more sources

Endothelial dysfunction and pathogenesis of diabetic angiopathy [PDF]

Cardiovascular Research, 1997
To review, from the clinical perspective, the contribution of dysfunction of the vascular endothelium to the pathogenesis of diabetic micro- and macroangiopathy.Available data indicate that endothelial dysfunction in diabetes complicated by micro- or macroalbuminuria (renal microangiopathy) is generalised. The close linkage between microalbuminuria and
Coen D.A. Stehouwer
semanticscholar   +6 more sources

Redox Status of β₂GPI in Different Stages of Diabetic Angiopathy. [PDF]

Dis Markers, 2016
We explored the redox status of beta 2 glycoprotein I (β 2GPI) in different stages of diabetic angiopathy. Type 2 diabetes mellitus (T2DM) had a significantly lower proportion of reduced β 2GPI as compared to healthy controls (p < 0.05).
Ma J, Zhang JY, Liu Y, Yu DM, Yu P.
europepmc   +4 more sources

Transcriptional profiling of mouse cavernous pericytes under high-glucose conditions: Implications for diabetic angiopathy. [PDF]

Investig Clin Urol, 2021
Purpose Penile erection requires integrative interactions between vascular endothelial cells, pericytes, smooth muscle cells, and autonomic nerves. Furthermore, the importance of the role played by pericytes in the pathogenesis of angiopathy has only ...
Yin GN, Wu J, Cui Y, Lin C, Shi L, Gao ZL, Suh JK, Ryu JK, Jin HR.   +8 more
europepmc   +3 more sources

Hippo/YAP signaling pathway: a new therapeutic target for diabetes mellitus and vascular complications. [PDF]

Ther Adv Endocrinol Metab, 2023
Diabetic angiopathy, which includes diabetic kidney disease (DKD), cardio-cerebrovascular disease, and diabetic retinopathy (DR) among other diseases, is one of the most common complications affecting diabetic patients. Among these, DKD, which is a major
Wei L, Gao J, Wang L, Tao Q, Tu C.
europepmc   +2 more sources

Alterations in the Processing of Platelet APP (Amyloid Beta Precursor Protein) in Alzheimer Disease: The Possible Nexus. [PDF]

Neuropsychopharmacol Rep
This review examines the role of activated platelets in Alzheimer disease (AD) pathology, highlighting their contribution to amyloid peptide (Aβ) accumulation and neurofibrillary tangles. While platelets normally support neuronal health and synaptic plasticity, their overactivation may exacerbate AD.
Al-Kuraishy HM, Sulaiman GM, Mohammed HA, Dawood RA, Albuhadily AK, Al-Gareeb AI, Abomughaid MM, Klionsky DJ.   +7 more
europepmc   +2 more sources

The m⁶A-ncRNAs axis in diabetes complications: novel mechanism and therapeutic potential. [PDF]

Front Endocrinol (Lausanne)
Diabetes, a multifaceted metabolic disorder, poses a significant global health burden with its increasing prevalence and associated complications, such as diabetic nephropathy, diabetic retinopathy, diabetic cardiomyopathy, and diabetic angiopathy ...
Yu S, Li C, Lu X, Han Z, Li Y, Yuan X, Guo D.   +6 more
europepmc   +2 more sources

Diabetic Foot and Fungal Infections: Etiology and Management from a Dermatologic Perspective. [PDF]

J Fungi (Basel)
Diabetes Mellitus (DM) is a significant global concern. Many diabetic patients will experience complications due to angiopathy, neuropathy, and immune dysfunction, namely diabetic foot ulcers (DFU) and diabetic foot infections (DFI), which can result in ...
Gupta AK, Shemer A, Economopoulos V, Talukder M.   +3 more
europepmc   +2 more sources