Results 71 to 80 of about 9,144 (265)

Bioenergetics and lipid metabolism in Alzheimer's disease: From cell biology to systemic health

Journal of Internal Medicine, Volume 299, Issue 1, Page 20-43, January 2026.
Abstract Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by progressive cognitive decline. Although amyloid‐β and tau pathologies remain central to our understanding of AD, growing evidence suggests that disrupted lipid metabolism and impaired bioenergetics are closely linked to these hallmark features. Genetic, lipidomic
Silvia Maioli, Ivan Nalvarte, Maria Ankarcrona, Marianne Schultzberg, Kristen L. Zuloaga, Julen Goikolea, Pieter Jelle Visser, Bart De Strooper, Bengt Winblad, Paola Pizzo, Pete A. Williams, Patricia Rodriguez‐Rodriguez, Luana Naia   +12 more
wiley   +1 more source

Heme oxygenase-1 activity as a correlate to exercise-mediated amelioration of cognitive decline and neuropathological alterations in an aging rat model of dementia [PDF]

, 2018
Alzheimer’s disease (AD) is a neurodegenerative disorder with cognitive impairment. Physical exercise has long been proven to be beneficial in the disorder.
Andrea Kurucz, Anikó Pósa, Balázs Varga, Béla Juhász, Dániel Priksz, György Trencsényi, Kurucz Andrea (2015-) (Orvos), Mariann Bombicz, Renáta Szabó, Rita Kiss, Rudolf Gesztelyi, Tibor Hortobágyi, Zoltán Szilvássy   +12 more
core   +2 more sources

Moyamoya Disease and the Risk of Parkinson's Disease

Annals of Clinical and Translational Neurology, Volume 12, Issue 12, Page 2523-2534, December 2025.
ABSTRACT Objectives Moyamoya disease (MMD) is a rare cerebrovascular disorder characterized by the progressive narrowing of arteries at the base of the brain, forming abnormal collateral vascular networks. While vascular parkinsonism is noted in MMD, its link to Parkinson's disease (PD) has not been explored.
Dallah Yoo, Jeong‐Yong Shin, Rugyeom Lee, Jiwon Cheon, Ji Hun Kim, Doeun Kim, Jae‐Kyung Won, In‐Hwan Oh, Yunjong Lee, Tae‐Beom Ahn   +9 more
wiley   +1 more source

Involvement of TAGE-RAGE System in the Pathogenesis of Diabetic Retinopathy

Journal of Ophthalmology, 2010
Diabetic complications are a leading cause of acquired blindness, end-stage renal failure, and accelerated atherosclerosis, which are associated with the disabilities and high mortality rates seen in diabetic patients.
Masayoshi Takeuchi, Jun-ichi Takino, Sho-ichi Yamagishi   +2 more
doaj   +1 more source

Serum cholesterol levels, HMG-CoA reductase inhibitors and the risk of intracerebral haemorrhage. the Multicenter Study on Cerebral Haemorrhage in Italy (MUCH-Italy) [PDF]

, 2016
Objective: Although a concern exists that 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) might increase the risk of intracerebral haemorrhage (ICH), the contribution of these agents to the relationship between serum cholesterol and ...
Agnelli, Giancarlo, Azzini, Cristiano, Bonaiti, Silvia, Bonifati, Domenico Marco, Bovi, Paolo, Calabrò, Rocco Salvatore, Cavallini, Anna, Chiti, Alberto, Ciccone, Alfonso, Colombi, Marina, Costa, Paolo, De Gaetano, Giovanni, De Giuli, Valeria, De Vito, Alessandro, Del Sette, Massimo, Del Zotto, Elisabetta, Delodovici, Maria Luisa, Di Castelnuovo, Augusto, Gamba, Massimo, Gandolfo, Carlo, Grassi, Mario, Iacoviello, Licia, La Spina, Paolo, Lanari, Alessia, Lodigiani, Corrado, Malferrari, Giovanni, Marcello, Norina, Marcheselli, Simona, Martini, Giuseppe, Micieli, Giuseppe, Morotti, Andrea, Musolino, Rossella, Paciaroni, Maurizio, Padovani, Alessandro, Pezzini, Alessandro, Poli, Loris, Pugliese, Nicola, Ritelli, Marco, Sessa, Maria, Silvestrelli, Giorgio, Tassi, Rossana, Tomelleri, Giampaolo, Toriello, Antonella, Vandelli, Laura, Zedde, Marialuisa, Zini, Andrea   +45 more
core   +1 more source

Restoring Histone Acetylation Accelerates Diabetic Wound Repair by Improving the Spatiotemporal Dynamics of Macrophages

Advanced Science, Volume 12, Issue 46, December 11, 2025.
Butyrate—via epigenetic modulation of the histone core—rebalance dysregulated macrophage function and promotes wound healing under persisting hostile conditions of diabetic mice. Additionally, butyrate harmonizes macrophage interactions with keratinocytes and fibroblasts as well as breaks the vicious cycle of inflammation in chronic wounds by restoring
Karmveer Singh, Albert Kallon Koroma, Rajeev Kumar Pandey, Yongfang Wang, Jinnan Cheng, Philipp Haas, Mahyar Aghapour, Linda Krug, Adelheid Hainzl, Meinhard Wlaschek, Pallab Maity, Karin Scharffetter‐Kochanek   +11 more
wiley   +1 more source

Application of antioxidant preparation Hepaval in rational therapy of diabetes mellitus

Mìžnarodnij Endokrinologìčnij Žurnal, 2018
Lecture presents the data on the current state of diabetes mellitus problem and the role of oxidative stress. In diabetes mellitus, there are ideal conditions for the development of oxidative stress, the main role in which is played by lipid peroxidation.
V.І. Pankiv, І.V. Pankiv
doaj   +1 more source

Retinal and cerebral microvascular signs and diabetes: the age, gene/environment susceptibility-Reykjavik study [PDF]

, 2010
To access publisher full text version of this article. Please click on the hyperlink in Additional Links fieldOBJECTIVE: Diabetes increases the risk for microvascular disease.
Cotch, Mary Frances, Eiriksdottir, Gudny, Garcia, Melissa, Gudnason, Vilmundur, Harris, Tamara B, Jonasson, Fridbert, Klein, Barbara E K, Klein, Ronald, Launer, Lenore J, Qiu, Chengxuan, Sigurdsson, Sigurdur, van Buchem, Mark A   +11 more
core   +1 more source

CSF markers of vascular injury correlate with tau and cognitive decline in early Alzheimer's disease

Alzheimer's &Dementia, Volume 21, Issue 12, December 2025.
Abstract INTRODUCTION Cerebrovascular injury is common in Alzheimer's disease (AD), but its timing in relation to Aβ and tau pathology and cognitive decline remains unclear. METHODS We measured baseline vascular marker levels in cerebrospinal fluid (CSF) and serum from 75 Alzheimer's Disease Neuroimaging Initiative (ADNI) study participants, stratified
J. Scott Miners, Gargi Roy, Seth Love, and for the Alzheimer's Disease Neuroimaging Initiative   +3 more
wiley   +1 more source

Some aspects of morphogenesis of diabetic encephalopathy

Zaporožskij Medicinskij Žurnal, 2013
On the basis of the literary data and conducted large-scale research it was ascertained that diabetes mellitus raises the risk of cerebral stroke in 2-6 times, the risk of transitional ischemic attacks in 3 times in comparison with the same risk in the ...
V. A. Tumanskiy, Yu. N. Avramenko
doaj   +1 more source