Results 71 to 80 of about 9,259 (266)

Involvement of TAGE-RAGE System in the Pathogenesis of Diabetic Retinopathy

Journal of Ophthalmology, 2010
Diabetic complications are a leading cause of acquired blindness, end-stage renal failure, and accelerated atherosclerosis, which are associated with the disabilities and high mortality rates seen in diabetic patients.
Masayoshi Takeuchi, Jun-ichi Takino, Sho-ichi Yamagishi   +2 more
doaj   +1 more source

Application of antioxidant preparation Hepaval in rational therapy of diabetes mellitus

Mìžnarodnij Endokrinologìčnij Žurnal, 2018
Lecture presents the data on the current state of diabetes mellitus problem and the role of oxidative stress. In diabetes mellitus, there are ideal conditions for the development of oxidative stress, the main role in which is played by lipid peroxidation.
V.І. Pankiv, І.V. Pankiv
doaj   +1 more source

Novel anti-obesity quercetin-derived Q2 prevents metabolic disorders in rats fed with high-fat diet [PDF]

, 2018
Objective: Obesity is often accompanied by an increased morbidity and mortality due to an increase of the cardiovascular disease risk factors, diabetes mellitus and dyslipidemia. Research is constantly working on protective molecules against obesity.
Albano, Luigi, Amelio, D, Angelone, Tommaso, Granieri, Mc, Macchia, Pe, Nettore, Ic, Rocca, C, Sinicropi, S, Ungaro, Paola   +8 more
core   +1 more source

Association of residential neighborhood disadvantage with amyloid PET positivity among cognitively impaired individuals

Alzheimer's &Dementia: Behavior &Socioeconomics of Aging, Volume 2, Issue 1, March 2026.
Abstract INTRODUCTION Relationships between Alzheimer's disease neuropathology, residential neighborhood, and cognitive impairment remain incompletely understood. METHODS We examined whether residence within a disadvantaged neighborhood was associated with amyloid positron emission tomography (PET) positivity.
Charles C. Windon, Elena Tsoy, Jennifer Livaudais‐Toman, Torsten B. Neilands, Nynikka R. Palmer, Margo B. Heston, Julene K. Johnson, Lucy Hanna, Constantine Gatsonis, Justin Romanoff, Jon Steingrimsson, Maria C. Carrillo, Peggye Dilworth‐Anderson, Bruce E. Hillner, Barry A. Siegel, Rachel A. Whitmer, Consuelo H. Wilkins, Karen Smith, Ganna Blazhenets, Renaud La Joie, Bruce L. Miller, Katherine L. Possin, Gil D. Rabinovici   +22 more
wiley   +1 more source

The Effect of Dietary and Exercise Self-Management Support Program on Dietary Behavior Exercise Behavior and Clinical Outcomes in Muslim Patients with Poorly Controlled Type 2 DM in a Community Setting in Indonesia [PDF]

, 2015
Purpose: The objective of this study was to examine the effect of dietary and exercise self-management support program on the dietary behavior, exercise behavior, and clinical outcomes of Muslim patients with poorly controlled type 2 DM in Indonesia ...
Chinnawong, T. (Tippamas), Kritpracha, C. (Charuwan), Pamungkas, R. A. (Rian)   +2 more
core   +1 more source

Müller Glial Kir4.1 Channel Dysfunction in APOE4‐KI Model of Alzheimer's Disease

Glia, Volume 74, Issue 3, March 2026.
APOE4 impairs Müller cell health by reducing Kir4.1 expression and buffering. APOE4 causes mitochondrial dysfunction with decreased ΔΨm and increased ROS. MitoQ restores Kir4.1 expression and reduces ROS in APOE4‐transfected cells. ABSTRACT Alzheimer's disease (AD), particularly late‐onset AD (LOAD), affects millions worldwide, with the apolipoprotein ...
Surabhi D. Abhyankar, Yucheng Xiao, Neha Mahajan, Qianyi Luo, Theodore R. Cummins, Adrian L. Oblak, Bruce T. Lamb, Timothy W. Corson, Ashay D. Bhatwadekar   +8 more
wiley   +1 more source

Prevention of Protein Glycation by Natural Compounds [PDF]

, 2015
Non-enzymatic protein glycosylation (glycation) contributes to many diseases and aging of organisms. It can be expected that inhibition of glycation may prolong the lifespan.
Bartosz, Grzegorz, Sadowska-Bartosz, Izabela   +1 more
core   +2 more sources

SGLT2 inhibitor or metformin as standard treatment in early‐stage type 2 diabetes? Baseline data in SMARTEST, a novel, decentralised, register‐based randomised trial on prevention of diabetic complications

Diabetes, Obesity and Metabolism, Volume 28, Issue 2, Page 1327-1338, February 2026.
Abstract Aims Metformin has hitherto not been proven superior to other type 2 diabetes (T2D) medications for the prevention of organ complications. The aim of this study is to report baseline data and blinded interim analyses in the register‐based randomised clinical trial (RRCT) SMARTEST, which compares metformin and the SGLT2 inhibitor dapagliflozin ...
Jan W. Eriksson, Giovanni Fanni, Martin H. Lundqvist, Stefan Jansson, Karin Rådholm, Sheyda Sofizadeh, Vagia Patsoukaki, Albert Nilsson, Daniel Lindholm, Olov Rolandsson, Anna Norhammar, Elisabet Granstam, Björn Eliasson, Louise Bennet, Johan Sundström   +14 more
wiley   +1 more source

Some aspects of morphogenesis of diabetic encephalopathy

Zaporožskij Medicinskij Žurnal, 2013
On the basis of the literary data and conducted large-scale research it was ascertained that diabetes mellitus raises the risk of cerebral stroke in 2-6 times, the risk of transitional ischemic attacks in 3 times in comparison with the same risk in the ...
V. A. Tumanskiy, Yu. N. Avramenko
doaj   +1 more source

Serum cholesterol levels, HMG-CoA reductase inhibitors and the risk of intracerebral haemorrhage. the Multicenter Study on Cerebral Haemorrhage in Italy (MUCH-Italy) [PDF]

, 2016
Objective: Although a concern exists that 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) might increase the risk of intracerebral haemorrhage (ICH), the contribution of these agents to the relationship between serum cholesterol and ...
Agnelli, Giancarlo, Azzini, Cristiano, Bonaiti, Silvia, Bonifati, Domenico Marco, Bovi, Paolo, Calabrò, Rocco Salvatore, Cavallini, Anna, Chiti, Alberto, Ciccone, Alfonso, Colombi, Marina, Costa, Paolo, De Gaetano, Giovanni, De Giuli, Valeria, De Vito, Alessandro, Del Sette, Massimo, Del Zotto, Elisabetta, Delodovici, Maria Luisa, Di Castelnuovo, Augusto, Gamba, Massimo, Gandolfo, Carlo, Grassi, Mario, Iacoviello, Licia, La Spina, Paolo, Lanari, Alessia, Lodigiani, Corrado, Malferrari, Giovanni, Marcello, Norina, Marcheselli, Simona, Martini, Giuseppe, Micieli, Giuseppe, Morotti, Andrea, Musolino, Rossella, Paciaroni, Maurizio, Padovani, Alessandro, Pezzini, Alessandro, Poli, Loris, Pugliese, Nicola, Ritelli, Marco, Sessa, Maria, Silvestrelli, Giorgio, Tassi, Rossana, Tomelleri, Giampaolo, Toriello, Antonella, Vandelli, Laura, Zedde, Marialuisa, Zini, Andrea   +45 more
core   +1 more source