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The Diabetic Foot

open access: yesMedicine, 2015
Diabetic foot infections are a frequent clinical problem. About 50% of diabetic foot infections who have foot amputations die within five years. Properly managed most can be cured, but many patients needlessly undergo amputations because of improper ...
J. Lubetzki   +2 more
semanticscholar   +5 more sources

pH/Glucose Dual Responsive Metformin Release Hydrogel Dressings with Adhesion and Self-Healing via Dual-Dynamic Bonding for Athletic Diabetic Foot Wound Healing.

ACS Nano, 2022
In view of the lack of a specific drug-sustained release system that is responsive to chronic wounds of the type II diabetic foot, and the demands for frequent movement at the foot wound, pH/glucose dual-responsive metformin-released adhesion-enhanced ...
Yongping Liang   +5 more
semanticscholar   +1 more source

The Diabetic Foot [PDF]

open access: possibleSurgical Clinics of North America, 2007
Lower extremity complications are common in patients with diabetes and include neuropathy, ulceration, infection, and peripheral arterial disease. Foot infections represent the single most common cause of hospitalization and lower extremity amputation in persons with diabetes. Foot ulceration as a result of diabetic peripheral sensory neuropathy, rigid
Charles A. Andersen, Thomas S. Roukis
openaire   +5 more sources

Strategy for Treatment of Infected Diabetic Foot Ulcers.

Accounts of Chemical Research, 2021
ConspectusDiabetic foot ulcers (DFUs) are chronic wounds that develop in 30% of diabetic patients. In DFUs, the normal wound healing process consisting of inflammation, angiogenesis, and extracellular matrix (ECM) remodeling is dysregulated and stalled ...
Mayland Chang, Trung T. Nguyen
semanticscholar   +1 more source

Global mortality of diabetic foot ulcer: A systematic review and meta‐analysis of observational studies

Diabetes, obesity and metabolism, 2022
To estimate the long‐term mortality and risk factors in patients with diabetic foot ulcer (DFU).
Lihong Chen   +3 more
semanticscholar   +1 more source

Bone marrow stromal cell‐derived exosomal circular RNA improves diabetic foot ulcer wound healing by activating the nuclear factor erythroid 2‐related factor 2 pathway and inhibiting ferroptosis

Diabetic Medicine, 2022
Diabetic foot ulcer (DFU) remains a serious chronic diabetic complication that can lead to disability. CircRNA‐itchy E3 ubiquitin protein ligase (circ‐ITCH) was observed to be down‐regulated in diabetic retinopathy and diabetic nephropathy, and ...
Juehao Chen   +9 more
semanticscholar   +1 more source

The Diabetic Foot [PDF]

open access: possibleJournal of the American Academy of Orthopaedic Surgeons, 1995
Management of foot problems in the patient with diabetes mellitus requires attention to each system affected by the disease. Appropriate treatment of common clinical problems affecting the foot in diabetic patients, such as ulcerations and fractures, depends on a thorough understanding of the pathophysiology of the disease.
Richard T. Laughlin   +2 more
openaire   +2 more sources

The Diabetic Foot

Orthopedics, 1987
ABSTRACT: Amputation of the lower extremity is more frequent in diabetic patients than in the general population. Causative factors include foot deformities, neuropathy, dysvascularity, infection, and gangrene. A grading and treatment program is outlined for aid in treating the lesions that develop in these feet.
M B, Zlatkin   +3 more
openaire   +4 more sources

Diabetic Foot Ulcers and Their Recurrence.

New England Journal of Medicine, 2017
Foot ulceration is the most common lower-extremity complication in patients with diabetes mellitus. This review considers the pathogenesis, treatment, and management of diabetic foot ulcers, including prevention of recurrence.
D. Armstrong, A. Boulton, S. Bus
semanticscholar   +1 more source

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