Results 171 to 180 of about 1,719,974 (229)

Safety and pharmacokinetics of anumigilimab for hidradenitis suppurativa or palmoplantar pustulosis: A phase 1b study

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Anumigilimab, a novel anti‐G‐CSF receptor antibody, was investigated in a phase 1b trial involving 39 patients with hidradenitis suppurativa or palmoplantar pustulosis. No serious safety concerns related to anumigilimab were noted, and PK and PD were dose dependent.
Johannes S. Kern, Simon Francis Thomsen, Georgios Kokolakis, Maurizio Podda, Gregor B. E. Jemec, Kurt Gebauer, Claus Zachariae, John Frew, Pablo Fernandez‐Peñas, Falk G. Bechara, Stefan Beissert, Sourabh Malandkar, Karen Scalzo‐Inguanti, Partha Nandy, Selvakumar Sukumar   +14 more
wiley   +1 more source

Higher Prevalence of Cancer in Patients with Diabetic Foot Syndrome. [PDF]

J Clin Med
Goretti C, Prete A, Brocchi A, Iacopi E, Pieruzzi L, Piaggesi A.   +5 more
europepmc   +1 more source

The Mean and Variability of Morning Hour Activity Over 2–3 Days Predict 5‐Year Mortality and Frailty Risk in a National Sample of Older Adults

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background Activity pattern features measured by continuous accelerometry are strongly associated with frailty, making accelerometry a promising, scalable screening tool for frailty. However, adherence to typical 5–7 day wear protocols decreases with age, reducing feasibility.
Megan Huisingh‐Scheetz, Sylvia Brown, Michelangelo Pagan, Cassidy Cabrera, Daniel Rubin, Nabiel Mir, Maria Lucia Madariaga, L. Philip Schumm, Kristen Wroblewski, Donald Hedeker   +9 more
wiley   +1 more source

Cumulative effects of lifelong systemic excess growth hormone on postcranial skeletal morphology in adult mice

Journal of Anatomy, EarlyView.
Our μCT‐based pilot study reveals size and shape disparity in the adult postcranial skeleton of growth‐hormone model (bGH) mice relative to wild‐type mice. bGH mice have larger and more sexually dimorphic bones, with a systemic radiodensity increase in bony sesamoids and associated, but typically uncalcified, soft tissues.
Joseph R. Groenke, Huanhuan Liu, Grace Lach, Abhishek Wajpe, Darlene Berryman, John J. Kopchick, Shouan Zhu, Patrick M. O'Connor   +7 more
wiley   +1 more source

Can acupuncture increase microcirculation in peripheral artery disease and diabetic foot syndrome? - a pilot study. [PDF]

Front Med (Lausanne)
Valentini J, Sigl M, Dunckel C, Krisam J, Amendt K, Greten HJ.   +5 more
europepmc   +1 more source

A Multimodal Machine Learning Model for Framingham Risk Score–Based Cardiovascular Risk Stratification in Patients With Obstructive Sleep Apnea

Journal of Sleep Research, EarlyView.
ABSTRACT Machine learning provides a powerful tool to capture complex, nonlinear patterns in biomedical data and enhance precision risk stratification. In this study, we applied a multilayer perceptron (MLP) framework to classify Framingham Risk Score–based cardiovascular risk categories in patients with obstructive sleep apnea (OSA).
Feng Zhao, Yin Li, Chenyang Li, Huajun Xu, Enhui Zhou, Weijun Huang, Huaming Zhu, Jian Guan, Hongliang Yi, Jianyin Zou, Nutan Chen   +10 more
wiley   +1 more source

Integrating Toe Brachial Index and longitudinal strain echocardiography for detecting coronary artery disease in patients with diabetic foot syndrome. [PDF]

Int Wound J
Moayerifar M, Moayerifar M, Mirdamadi A, Gholipour M, Ashoobi MT, Hemmati H, Yazdanipour MA, Radmoghadam M, Ghasemzadeh G.   +8 more
europepmc   +1 more source

Looking for trouble: A common threat‐detection mechanism underlying pain, fear, and anxiety

Mind &Language, EarlyView.
I put forward a novel cognitive architecture for pain, fear, and anxiety, according to which these three capacities are underpinned by a common threat‐detection mechanism. This mechanism takes information about potential threats as input, assesses whether the threat is actual and, if it deems it is, outputs a threat representation.
Luca Barlassina
wiley   +1 more source

Targeting Overweight and Obesity Phenotypes for Secondary Prevention of Cardiovascular Disease: A Call to Action for the Middle East and Beyond

Obesity Reviews, EarlyView.
ABSTRACT Although there are conflicting clinical data on the efficacy of weight reduction in reducing secondary events in patients with comorbid overweight and obesity (OAO) and cardiovascular disease (CVD), there is excellent epidemiological and biological evidence of a cause–effect relationship between OAO, CVD, and other systemic complications ...
Wael Almahmeed, Juan S. Barajas‐Gamboa, Mohammad Zubaid, Ebaa Al Ozairi, Abdullah Shehab, Khalid Al‐Rasadi, Charbel Abi Khalil, Noor Al Busaidi, Fahad Al Sindi, Zuhier Awan, Tomader Ali, Khaldoon Al‐Humood, Fatheya Al Awadi, Mohammed Al Hadad, Manal Al Kindi, Khalid Al Habib, Khalid Al Waili, Maryam Alsaeed, Adel Tash, Hani Sabbour   +19 more
wiley   +1 more source

Doppler Sonographic Characteristics and Clinical Outcomes of Diabetic Foot Syndrome: A 5-Year Audit from a Tertiary Hospital in Northern Nigeria. [PDF]

J West Afr Coll Surg
Ismail A, Lawal Y, Gezawa ID, Ramalan MA, Uloko AE, Usman MI.   +5 more
europepmc   +1 more source