Results 111 to 120 of about 6,394 (171)

Fingolimod: therapeutic mechanisms and ocular adverse effects. [PDF]

, 2017
Fingolimod is an oral immunomodulating drug used in the management of relapsing-remitting multiple sclerosis (RRMS). We aim to review the published literature on ocular manifestations of fingolimod therapy and their possible underlying mechanisms.
A Groves, A Gupta, A Minuk, A Schwarz, AR Afshar, B Nealon, BJ McVerry, C Aguiar, D Ontaneda, G Saab, H Chen, H Tedesco-Silva, J Camm, J Chui, J Chun, JA Cohen, JA Cohen, JM Gelfand, K Schroder, K Turaka, L Kappos, L Kappos, L Liu, M Brar, M Salvadori, MA Zarbin, ML Oo, MT Bhatti, N Ueda, OJ Coppes, P A Keane, P Mandal, PA Calabresi, R Gallego-Pinazo, R Moosavi, RS Brush, S Thoo, V Li, VM Asensio-Sanchez, W Fusi-Rubiano, Y Yang   +40 more
core   +1 more source

An Unprecedented Triad: Simultaneous Acute Pancreatitis, Axonal Polyneuropathy, and Type 1 Diabetes Mellitus in a Catastrophic Juvenile Lupus Flare

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT A 14‐year‐old female with juvenile systemic lupus erythematosus (jSLE) presented with a life‐threatening and previously unreported triad: the simultaneous onset of acute pancreatitis, severe axonal polyneuropathy, and autoimmune Type 1 Diabetes (T1D).
Laiba Hashmi, Fazeela Bibi, Kishan Chand Lohana, Khalil El Abdi, Zonaira Mushahid, Muhammad Asad Asif, Mahnoor Ilyas, Osvani Leyva Matos, Ariba Munam, Muhammad Saad Sammi, Samaha Kanden Mohammed Shafi, Said Hamid Sadat   +11 more
wiley   +1 more source

Combined therapy in diabetic macular edema [PDF]

, 2015
Purpose: To determine the effectiveness of three different combinations for the ‘‘loading phase’’ in the treatment of diabetic macular edema (DME), using bevacizumab (BVZ), triamcinolone (TCL) and subthreshold macular photocoagulation (SMPC).
Butrón Valdez, K., González Cortés, Jesús Hernán, Guerra Leal, Jesús Dante, Martínez Gamero, Bertha Olivia, Mohamed Hamsho, Jesús, Toledo Negrete, Juan José, Treviño Cavazos, Ezequiel Enrique, Zapata Elizondo, V.   +7 more
core  

United Kingdom Diabetic Retinopathy Electronic Medical Record (UK DR EMR) Users Group: report 4, real-world data on the impact of deprivation on the presentation of diabetic eye disease at hospital services. [PDF]

, 2018
AIM: To assess the impact of deprivation on diabetic retinopathy presentation and related treatment interventions, as observed within the UK hospital eye service.
Akerele, T., Antcliff, R., Bailey, C., Brand, C., Chakravarthy, U., Chavan, R., Cook, E., Crabb, D. P., Denniston, A. K., Dhingra, N., Downey, L., Egan, C. A., Eleftheriadis, H., Ghanchi, F., Khan, R., Kumar, V., Lee, A. Y., Lee, C. S., Lip, P-L., Lobo, A., Lotery, A., Menon, G., Mukherjee, R., Palmer, H., Patra, S., Paul, B., Pikoula, M., Sim, D. A., Talks, J. S., Taylor, P., Tufail, A., Wilkinson, E.   +31 more
core   +3 more sources

Irigenin Modulates BL‐Induced Pyroptosis in Retinal Pigment Epithelial Cells Through p38 MAPK and NFκB Pathways

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 2, February 2026.
Irigenin alleviates blue light‐induced RPE cell damage by inhibiting NLRP3 inflammasome and p38/NF‐κB signalling, showing potential for AMD prevention. ABSTRACT Age‐related macular degeneration (AMD), a primary cause of vision loss among older adults, is strongly associated with inflammatory processes.
I‐Li Su, Kun‐Lin Yeh, Chien‐Ying Lee, Sheng‐Chien Lin, Chen‐Yu Chiang, Chun‐Jung Chen, Wen‐Ying Chen, Ching‐Chi Tseng, Yin‐Che Lu, Yu‐Hsiang Kuan   +9 more
wiley   +1 more source

Prevalence and risk factors for diabetic retinopathy in a cross-sectional population-based study from rural southern China: Dongguan Eye Study

BMJ Open, 2019
Research question The current population-based study aimed to investigate the prevalence of diabetic retinopathy (DR) and risk factors among residents over 40 years old in the rural area of Dongguan, southern China.Study design The Dongguan Eye Study was
Liang Zhang, Jian Kuang, Ying Cui, Lixin Zhang, Guanrong Zhang, Qingyang Liu, Haike Guo, Qianli Meng   +7 more
doaj   +1 more source

Advances in Therapeutic Antibody Discovery and Development Targeting G Protein‐Coupled Receptors

Pharmacology Research &Perspectives, Volume 14, Issue 1, February 2026.
ABSTRACT G protein‐coupled receptors (GPCRs) are integral to numerous biological processes and are associated with various diseases across all therapeutic areas. Consequently, GPCRs present substantial potential for antibody‐based therapies. This review offers an overview of the therapeutic GPCR‐antibody target landscape and examines the diversity ...
Catherine J. Hutchings, Serbülent Ünsal, Mathieu Rappas, Matthew Barnes, Maria Waldhoer, Ben Holland, Martin Culka   +6 more
wiley   +1 more source

Test–retest variability of the full‐field stimulus test in patients with retinitis pigmentosa: REPEAT Study Report No. 4

Acta Ophthalmologica, Volume 104, Issue 1, Page 89-97, February 2026.
Abstract Purpose To evaluate test–retest variability (TRV) of the full‐field stimulus test (FST) in patients with retinitis pigmentosa (RP) and poor best‐corrected visual acuity (BCVA; ≤20/50 Snellen; ≥0.40 logMAR), and to assess the reliability of FST as a clinical endpoint in future RP trials.
J. S. Karuntu, S. B. A. E. Tulp, C. J. F. Boon   +2 more
wiley   +1 more source

STUDY OF CHANGE IN MACULAR VOLUME WITH UNCONTROLLED HBA1C LEVELS IN A DIABETIC PATIENT IN ABSENCE OF DIABETIC MACULAR OEDEMA

National Journal of Medical Research, 2016
Background: This study is aimed to find out the correlation between change in macular volume on optical coherence tomography (OCT) in patients with uncontrolled HbA1c levels . Methods: It is a observational study.
Parag Apte, Priti Kumari, Debapriya Datta, Nilesh Jagdale, Jatin Patel, Richa Naik   +5 more
doaj  

Management of anterior chamber dislocation of a dexamethasone intravitreal implant: a case report [PDF]

, 2016
Background Ozurdex is a 700 mcg dexamethasone intravitreal implant, approved for the management of macular edema secondary to retinal vein occlusion, and other related pathoglogiesAnterior chamber dislocation of Ozurdex represents an uncommon ...
AGOSTINELLI, Enzo, CARLESIMO, Sandra Cinzia, Forastiere, Michele, NEBBIOSO, Marcella, PACELLA, Elena, PACELLA, FERNANDA, SECONDI, ROBERTO   +6 more
core   +1 more source