Results 71 to 80 of about 6,394 (171)

IL-17A Damages the Blood–Retinal Barrier through Activating the Janus Kinase 1 Pathway

Biomedicines, 2021
Blood–retinal barrier (BRB) dysfunction underlies macular oedema in many sight-threatening conditions, including diabetic macular oedema, neovascular age-related macular degeneration and uveoretinitis.
Eimear M. Byrne, María Llorián-Salvador, Miao Tang, Andriana Margariti, Mei Chen, Heping Xu   +5 more
doaj   +1 more source

Anti-vascular endothelial growth factor for proliferative diabetic retinopathy. [PDF]

, 2014
BACKGROUND: Proliferative diabetic retinopathy (PDR) is a complication of diabetic retinopathy that can cause blindness. Although panretinal photocoagulation (PRP) is the treatment of choice for PDR, it has secondary effects that can affect vision.
Buil-Calvo, José A, Cordero, Josep A, Evans, Jennifer R, Martinez-Zapata, Maria José, Martí-Carvajal, Arturo J, Pijoán, José I, Solà, Ivan   +6 more
core   +2 more sources

Associations Between Initial Glycated Hemoglobin at Diabetes Diagnosis, Longitudinal Changes and Medication Effects, and the Severity and Progression of Sight‐Threatening Diabetic Retinopathy

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Diabetic retinopathy (DR) is a leading cause of vision impairment in patients diagnosed with Type 2 diabetes mellitus (T2DM). Awareness of risk factors is necessary to reduce or prevent harmful effects of DR such as irreversible vision loss, and to help ensure early treatment.
Yu‐Chi Sung, Yu‐Kuang Chen, Ching‐An Chen, Pei‐Kang Liu, Kai‐Chun Cheng, Wei‐Shan Chang, Chia‐Li Tseng, Hui‐Min Hsieh, Shwu‐Jiuan Sheu   +8 more
wiley   +1 more source

Anti-VEGF Therapy and the Retina: An Update

Journal of Ophthalmology, 2015
Ocular angiogenesis and macular oedema are major causes of sight loss across the world. Aberrant neovascularisation, which may arise secondary to numerous disease processes, can result in reduced vision as a result of oedema, haemorrhage, and scarring ...
Vikas Tah, Harry O. Orlans, Jonathan Hyer, Edward Casswell, Nizar Din, Vishnu Sri Shanmuganathan, Louise Ramskold, Saruban Pasu   +7 more
doaj   +1 more source

Why do patients still require surgery for the late complications of Proliferative Diabetic Retinopathy? [PDF]

, 2010
Aim - To briefly review and discuss the literature on why patients still require surgery for the late complications of proliferative diabetic retinopathy (PDR).\ud Methods: Literature review.\ud \ud \ud Results - The reasons for incomplete coverage of ...
Scanlon, Peter H
core   +1 more source

Reproducibility in the identification of retinal positions on serial fundus photographs: Theory and limitations

Acta Ophthalmologica, EarlyView.
Abstract Background Imaging of the retina is accompanied by distortions so that positions in fundus photographs cannot be linearly translated to positions in the retinal fundus. The purpose of this study was to describe an algorithm and evaluate its reproducibility in identifying points on the retina from their representation on serial fundus ...
Toke Bek, Giovanni Ometto
wiley   +1 more source

Lower Hemoglobin Concentration Is Associated with Retinal Ischemia and the Severity of Diabetic Retinopathy in Type 2 Diabetes

Journal of Diabetes Research, 2016
Aims. To assess the association of blood oxygen-transport capacity variables with the prevalence of diabetic retinopathy (DR), retinal ischemia, and macular oedema in patients with type 2 diabetes mellitus (T2DM). Methods.
Alicia Traveset, Esther Rubinat, Emilio Ortega, Nuria Alcubierre, Beatriz Vazquez, Marta Hernández, Carmen Jurjo, Ramon Espinet, Juan Antonio Ezpeleta, Didac Mauricio   +9 more
doaj   +1 more source

Integrated results from the COPERNICUS and GALILEO studies. [PDF]

, 2017
OBJECTIVES: To report on the efficacy and safety of intravitreal aflibercept in patients with macular edema secondary to central retinal vein occlusion (CRVO) in an integrated analysis of COPERNICUS and GALILEO.
Ahlers, Christiane, Asmus, Friedrich, Boyer, David S., Clark, W. Lloyd, Haller, Julia A., Holz, Frank G., Korobelnik, Jean-Francois, Ogura, Yuichiro, Pielen, Amelie, Rittenhouse, Kay D., Saroj, Namrata, Stemper, Brigitte, Vitti, Robert, Zeitz, Oliver   +13 more
core   +3 more sources

SD‐OCT‐based biomarkers in predicting treatment outcomes of macular oedema secondary to retinal vein occlusion treated with anti‐VEGF therapy

Acta Ophthalmologica, EarlyView.
Abstract Purpose To investigate the role of spectral domain optical coherence tomography (SD‐OCT)‐based biomarkers in predicting treatment response of macular oedema (MO) secondary to retinal vein occlusion (RVO) to anti‐vascular endothelial growth factor (VEGF) therapy.
Ken K. Tsang, Vivian W. K. Hui, Christopher M. K. Pang, Ziqi Tang, Dawei Yang, Truong X. Nguyen, Shaheeda Mohamed, Timothy Y. Y. Lai, Carol Y. Cheung, Simon K. H. Szeto   +9 more
wiley   +1 more source

Image-processing pipeline for diagnosing diabetic macular ischaemia in diabetic macular oedema

Scientific Reports
Diabetic Macular Ischaemia (DMI) is a critical cause of vision loss, frequently occurring alongside Diabetic Macular Oedema (DMO) in patients with severe diabetic retinopathy.
Xiaofan Xiong, Maged Habib, David H. Steel, Chingning Taffeta Yamaguchi, Tunde Peto, Boguslaw Obara   +5 more
doaj   +1 more source