Results 121 to 130 of about 697,452 (285)

Neuropathy - gait changes in the diabetic foot [PDF]

, 2008
Motor neuropathy in patients with diabetes can lead to weakness in the muscles of the foot and lower leg, which in turn can lead to characteristic changes to the structure of the foot, such as an altered arch profile.
McIntosh, Caroline, Newton, Veronica
core  

Neuropathic pain clinical trials:factors associated with decreases in estimated drug efficacy [PDF]

, 2018
Multiple recent pharmacological clinical trials in neuropathic pain have failed to show beneficial effect of drugs with previously demonstrated efficacy, and estimates of drug efficacy seems to have decreased with accumulation of newer trials.
Andersen, Niels T., Attal, Nadine, Baron, Ralf, Dworkin, Robert H., Finnerup, Nanna B., Gilron, Ian, Haanpaa, Maija L., Haroutounian, Simon, Jensen, Troels S., Kamerman, Peter R., McNicol, Ewan, Moore, Andrew, Raja, Srinivasa N., Rice, Andrew S. C., Sena, Emily, Smith, Blair   +15 more
core   +2 more sources

A brain-based pain facilitation mechanism contributes to painful diabetic polyneuropathy

Brain : a journal of neurology, 2018
Diabetic polyneuropathy is a leading cause of chronic neuropathic pain, but the mechanism underlying this link is unknown. Using a multimodal neuroimaging approach, Segerdahl et al.
A. Segerdahl, Andreas C Themistocleous, D. Fido, D. Bennett, I. Tracey   +4 more
semanticscholar   +1 more source

A Difficult‐to‐Manage Case of Primary Idiopathic Erythromelalgia—Case Report

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT Erythromelalgia is a rare condition with symptoms of erythema, warmth, and painful extremities exacerbated by warmth and relieved by cooling. Pain management is often challenging. The sodium channel blocker, lacosamide, was most effective in this patient.
Sarah Wide, Rajish S. K. Shil, Bernhard Frank, Viraj Bharambe   +3 more
wiley   +1 more source

Residual beta-Cell Function 3-6 Years After Onset of Type 1 Diabetes Reduces Risk of Severe Hypoglycemia in Children and Adolescents [PDF]

, 2013
OBJECTIVETo determine the prevalence of residual -cell function (RBF) in children after 3-6 years of type 1 diabetes, and to examine the association between RBF and incidence of severe hypoglycemia, glycemic control, and insulin requirements.RESEARCH ...
Birkebaek, N. H., Brorsson, C., Danish Soc Diabet, Childhood, Hertel, N. T., Johannesen, J., Kjaersgaard, P., Kristensen, K., Pociot, F., Sorensen, J. S., Thomsen, Jane   +9 more
core   +1 more source

Painful and non‐painful diabetic polyneuropathy: Clinical characteristics and diagnostic issues

Journal of Diabetes Investigation, 2019
Diabetic neuropathy (DN) is a common complication of diabetes and can be either painful or non‐painful. It is challenging to diagnose this complication, as no biomarker or clear consensus on the clinical definition of either painful or non‐painful DN ...
S. S. Gylfadottir, Danita Weeracharoenkul, S. T. Andersen, S. Niruthisard, S. Suwanwalaikorn, T. Jensen   +5 more
semanticscholar   +1 more source

Application and Challenges of Chimeric Antigen Receptor T Cell Therapy in Systemic Rheumatic Diseases and Autoimmune Disorders

MedComm, Volume 7, Issue 4, April 2026.
CAR‐T cell therapy in systemic rheumatic diseases and autoimmune disorders. (This figure was created using BioRender.com.) ABSTRACT Chimeric antigen receptor T (CAR‐T) cell therapy, originally developed for hematologic malignancies, has emerged as a transformative candidate for systemic rheumatic diseases and autoimmune disorders (AIDs).
Zhidan Fan, Li Zhang, Haiguo Yu
wiley   +1 more source

Glucose availability and sensitivity to anoxia of isolated rat peripheral nerve [PDF]

, 1991
The contrast between resistance to ischemia and ischemic lesions in peripheral nerves of diabetic patients was explored by in vitro experiments. Isolated and desheathed rat peroneal nerves were incubated in the following solutions with different glucose ...
DYCK P. J., GRAFE P., K., GREENE D. A, KRAIG R. P., M. Strupp, P. Grafe, R. Jund, SIESJO B. K, STRUPP M., R., THOMAS P. K., U. Schneider, W.   +11 more
core   +1 more source

Detection of early motor involvement in diabetic polyneuropathy using a novel MUNE method - MScanFit MUNE.

Clinical Neurophysiology, 2019
OBJECTIVE Detection of motor involvement in diabetic polyneuropathy (DPN) by nerve conduction studies (NCS) does not occur until there is substantial loss of motor units, because collateral reinnervation maintains compound muscle action potential (CMAP ...
A. Kristensen, Hugh Bostock, Nanna B. Finnerup, H. Andersen, T. Jensen, S. S. Gylfadottir, M. Itani, T. Krøigård, Søren H Sindrup, H. Tankişi   +9 more
semanticscholar   +1 more source

Unraveling Chronic Pain: From Mechanisms and Risks to Diagnosis and Treatment

MedComm, Volume 7, Issue 4, April 2026.
Chronic pain arises through distinct molecular pathways categorized into nociceptive, neuropathic, and nociplastic types. Nociceptive pain begins with TRP channel activation in peripheral nociceptors, signaling via Aδ‐ and C‐fibers through the spinal dorsal horn and spinothalamic tracts to the brain, regulated by descending inhibition and involving ...
Xiaofeng Dai, Chongxiang Wang, Ping Jiang, Xiaopeng Mei   +3 more
wiley   +1 more source