Results 281 to 290 of about 848,177 (365)

Synthetic microneurotrophins: Neurotrophin receptors for therapeutics of neurodegenerative diseases

British Journal of Pharmacology, EarlyView.
Neurodegenerative disorders are characterised by the chronic progressive degeneration of specific neuronal subtypes, neuroinflammation, myelin damage and synaptic loss. Despite their growing incidence, advancements in effective treatments remain limited, because of lack of knowledge for the aetiology of the diverse pathophysiology to design systematic ...
Ioanna Zota, Theodora Calogeropoulou, Konstantina Chanoumidou, Ioannis Charalampopoulos, Achille Gravanis   +4 more
wiley   +1 more source

Emerging role of circular RNAs in diabetic retinopathy. [PDF]

Korean J Physiol Pharmacol
Kim H, Ryu J.
europepmc   +1 more source

Potential Impact of Parental Origin of Inheritance on the Clinical Presentation of Familial Partial Lipodystrophy Type 2 Syndrome

Clinical Endocrinology, EarlyView.
ABSTRACT Context Familial partial lipodystrophy type 2 (FPLD2) is a rare autosomal dominant disorder caused by pathogenic variants in the LMNA gene. The influence of parental inheritance on clinical presentation has not been fully explored. Objective To investigate the influence of maternal versus paternal inheritance of LMNA variants on the clinical ...
Donatella Gilio, Ozge Besci, Natália Rossin Guidorizzi, Merve Celik Guler, Ilgin Yildirim Simsir, Caterina Pelosini, Giovanni Ceccarini, Korcan Demir, Baris Akinci, Ferruccio Santini, ECLip (European Consortium of Lipodystrophy), Maria Cristina Foss‐Freitas, Elif A. Oral   +12 more
wiley   +1 more source

The Prevalence of Diabetic Retinopathy in the 21st Century: New Insights From a Portuguese Center. [PDF]

Cureus
Moreira Martins P, Leite S, Teixeira S, Castro Cabanas J, Silva L, Sousa-Neves F.   +5 more
europepmc   +1 more source

Real‐World 10‐Year Outcomes of Anti‐VEGF Therapy for Neovascular Age‐Related Macular Degeneration: A Meta‐Analysis

Clinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Background This study examines the long‐term effectiveness of anti‐VEGF therapy in managing neovascular age‐related macular degeneration (nAMD). Despite the well‐established short‐term improvements of anti‐VEGF therapy, there is limited data on its continued efficacy over extended periods.
Kimberly Spooner, Geoffrey Broadhead, Samantha Fraser‐Bell, Thomas Hong, James G. Wong, Andrew A. Chang   +5 more
wiley   +1 more source

Bidirectional link between mood disorders and diabetic retinopathy. [PDF]

World J Psychiatry
Singh A, Morya AK, Nishant P, Sinha S.
europepmc   +1 more source

Development and Validation of a Deep Learning System for the Provision of a District‐Wide Diabetes Retinal Screening Service

Clinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Background Artificial intelligence (AI) enhanced retinal screening could reduce the impact of diabetic retinopathy (DR), the leading cause of preventable blindness in Australia. This study assessed the performance and validity of a dual‐modality, deep learning system for detection of vision‐threatening diabetic retinopathy (vtDR) in a multi ...
Jason R. Daley, Xingdi Wang, Natalie Ngo, Chee L. Khoo, Peter Heydon, Gerald Liew, Vallimayil Vallayutham, Tobias Kongbrailatpam, Uchechukwu L. Osuagwu, Marko Andric, Wei Xuan, David Simmons, Shweta Kaushik   +12 more
wiley   +1 more source

Retinal Vessel Traits and Age‐Related Eye Disease in the Canadian Longitudinal Study on Aging

Clinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Background To cross‐sectionally and longitudinally examine whether retinal vessel traits are associated with glaucoma‐related outcomes (glaucoma, cup‐to‐disc ratio [CDR] and intraocular pressure [IOP]) and age‐related macular degeneration (AMD).
Alexis O'Neil, Roshan A. Welikala, Sarah Barman, Christopher G. Owen, Alicja R. Rudnicka, Mohan Rakesh, Marie‐Hélène Roy‐Gagnon, David Maberley, Ellen E. Freeman   +8 more
wiley   +1 more source

Barriers and Enablers Influencing the Implementation of Artificial Intelligence for Diabetic Retinopathy Screening in Clinical Practice: A Scoping Review

Clinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Background Diabetic retinopathy is a leading cause of preventable blindness worldwide. Meanwhile, artificial intelligence is rapidly growing in clinical utility within medicine. This scoping review aims to identify and summarise existing literature on the barriers and enablers of clinical applications of artificial intelligence systems for the
Jenny Tran, Jose J. Estevez, Natasha J. Howard, Saravana Kumar   +3 more
wiley   +1 more source

Diabetic retinopathy and Alzheimer's disease: Convergence of the unfolded protein response in neurodegeneration. [PDF]

Alzheimers Dement
Palacios AG, Zhang SX, Acosta ML.
europepmc   +1 more source